| 9/2/2022 | Eastern Kentucky (7-5) | 34 | at | Eastern Michigan | 42 | ASUN (1AA) | ||
| 9/10/2022 | Eastern Michigan | 21 | at | UL Lafayette (6-7) | 49 | at SBC | ||
| 9/17/2022 | Eastern Michigan | 30 | at | Arizona State (3-9) | 21 | at P12 | ||
| 9/24/2022 | Buffalo (7-6,5-3) | 50 | at | Eastern Michigan | 31 | |||
| 10/1/2022 | Massachusetts (1-11) | 13 | at | Eastern Michigan | 20 | Ind | ||
| 10/8/2022 | Eastern Michigan | 45 | at | Western Michigan (5-7,4-4) | 23 | |||
| 10/15/2022 | Northern Illinois (3-9,2-6) | 39 | at | Eastern Michigan | 10 | |||
| 10/22/2022 | Eastern Michigan | 20 | at | Ball State (5-7,3-5) | 16 | |||
| 10/29/2022 | Toledo (9-5,6-3) | 27 | at | Eastern Michigan | 24 | |||
| 11/8/2022 | Eastern Michigan | 34 | at | Akron (2-10,1-7) | 28 | |||
| 11/16/2022 | Eastern Michigan | 31 | at | Kent State (5-7,4-4) | 24 | |||
| 11/25/2022 | Central Michigan (4-8,3-5) | 19 | at | Eastern Michigan | 38 | |||
| 12/20/2022 | Eastern Michigan | 41 | vs | San Jose State (7-5) | 27 | Boise ID | vs MW |
| vs Eastern Michigan | vs Other Opponents | Eastern Michigan compared to OOs | |
| Record: | 4-9 | 60-87 | |
| Points Scored: | 28.46 | 25.43 | -3.03 |
| Points Allowed: | 29.77 | 28.14 | 1.63 |
| Margin: | -1.31 | -2.71 | -1.40 |
| Total Points: | 58.23 | 53.57 | 4.66 |