| 9/1/2016 | UNC-Charlotte | 14 | at | Louisville | 70 | CUSA | ||
| William & Mary | 14 | at | North Carolina State | 48 | CAAF (1AA) | |||
| Tulane | 3 | at | Wake Forest | 7 | AAC | |||
| 9/2/2016 | Colgate | 7 | at | Syracuse | 33 | Pat (1AA) | ||
| 9/3/2016 | Clemson | 19 | at | Auburn | 13 | @ SEC | ||
| Georgia Tech | 17 | vs | Boston College | 14 | Dublin IE | |||
| North Carolina Central | 6 | at | Duke | 49 | MEAC (1AA) | |||
| North Carolina | 24 | vs | Georgia | 33 | Atlanta GA | vs SEC | ||
| Florida A&M | 3 | at | Miami-Florida | 70 | MEAC (1AA) | |||
| Villanova | 7 | at | Pittsburgh | 28 | CAAF (1AA) | |||
| Richmond | 37 | at | Virginia | 20 | CAAF (1AA) | |||
| Liberty | 13 | at | Virginia Tech | 36 | BigS (1AA) | |||
| 9/5/2016 | Mississippi | 34 | vs | Florida State | 45 | Orlando FL | vs SEC | |
| 9/9/2016 | Louisville | 62 | at | Syracuse | 28 | |||
| 9/10/2016 | Troy | 24 | at | Clemson | 30 | SBC | ||
| Wake Forest | 24 | at | Duke | 14 | ||||
| North Carolina State | 30 | at | East Carolina | 33 | @ AAC | |||
| Charleston Southern | 8 | at | Florida State | 52 | BigS (1AA) | |||
| Mercer | 10 | at | Georgia Tech | 35 | SoCon (1AA) | |||
| North Carolina | 48 | at | Illinois | 23 | @ B10 | |||
| Boston College | 26 | vs | Massachusetts | 7 | Foxboro MA | vs MAC | ||
| Florida Atlantic | 10 | at | Miami-Florida | 38 | CUSA | |||
| Virginia | 26 | at | Oregon | 44 | @ P12 | |||
| Penn State | 39 | at | Pittsburgh | 42 | B10 | |||
| Virginia Tech | 24 | vs | Tennessee | 45 | Bristol TN | vs SEC | ||
| 9/17/2016 | Miami-Florida | 45 | at | Appalachian State | 10 | @ SBC | ||
| South Carolina State | 0 | at | Clemson | 59 | MEAC (1AA) | |||
| Virginia | 10 | at | Connecticut | 13 | @ AAC | |||
| Vanderbilt | 7 | at | Georgia Tech | 38 | SEC | |||
| Florida State | 20 | at | Louisville | 63 | ||||
| James Madison | 28 | at | North Carolina | 56 | CAAF (1AA) | |||
| Old Dominion | 22 | at | North Carolina State | 49 | CUSA | |||
| Duke | 13 | at | Northwestern | 24 | @ B10 | |||
| Pittsburgh | 38 | at | Oklahoma State | 45 | @ B12 | |||
| South Florida | 45 | at | Syracuse | 20 | AAC | |||
| Boston College | 0 | at | Virginia Tech | 49 | ||||
| Delaware | 21 | at | Wake Forest | 38 | CAAF (1AA) | |||
| 9/22/2016 | Clemson | 26 | at | Georgia Tech | 7 | |||
| 9/24/2016 | Wagner | 10 | at | Boston College | 42 | NE (1AA) | ||
| Syracuse | 31 | at | Connecticut | 24 | @ AAC | |||
| Wake Forest | 33 | at | Indiana | 28 | @ B10 | |||
| Louisville | 59 | at | Marshall | 28 | @ CUSA | |||
| Pittsburgh | 36 | at | North Carolina | 37 | ||||
| Duke | 38 | at | Notre Dame | 35 | @ ND | |||
| Florida State | 55 | at | South Florida | 35 | @ AAC | |||
| Central Michigan | 35 | at | Virginia | 49 | MAC | |||
| East Carolina | 17 | at | Virginia Tech | 54 | AAC | |||
| 10/1/2016 | Buffalo | 3 | at | Boston College | 35 | MAC | ||
| Louisville | 36 | at | Clemson | 42 | ||||
| Virginia | 34 | at | Duke | 20 | ||||
| North Carolina | 37 | at | Florida State | 35 | ||||
| Miami-Florida | 35 | at | Georgia Tech | 21 | ||||
| Wake Forest | 16 | at | North Carolina State | 33 | ||||
| Marshall | 27 | at | Pittsburgh | 43 | CUSA | |||
| Notre Dame | 50 | vs | Syracuse | 33 | East Rutherford NJ | vs ND | ||
| 10/7/2016 | Clemson | 56 | at | Boston College | 10 | |||
| 10/8/2016 | Army | 6 | at | Duke | 13 | Ind | ||
| Florida State | 20 | at | Miami-Florida | 19 | ||||
| Virginia Tech | 34 | at | North Carolina | 3 | ||||
| Notre Dame | 3 | at | North Carolina State | 10 | ND | |||
| Georgia Tech | 34 | at | Pittsburgh | 37 | ||||
| Syracuse | 9 | at | Wake Forest | 28 | ||||
| 10/14/2016 | Duke | 14 | at | Louisville | 24 | |||
| 10/15/2016 | North Carolina State | 17 | at | Clemson | 24 | OT | ||
| Wake Forest | 6 | at | Florida State | 17 | ||||
| Georgia Southern | 24 | at | Georgia Tech | 35 | SBC | |||
| North Carolina | 20 | at | Miami-Florida | 13 | ||||
| Virginia Tech | 17 | at | Syracuse | 31 | ||||
| Pittsburgh | 45 | at | Virginia | 31 | ||||
| 10/20/2016 | Miami-Florida | 16 | at | Virginia Tech | 37 | |||
| 10/22/2016 | Syracuse | 28 | at | Boston College | 20 | |||
| North Carolina State | 13 | at | Louisville | 54 | ||||
| North Carolina | 35 | at | Virginia | 14 | ||||
| 10/27/2016 | Virginia Tech | 39 | at | Pittsburgh | 36 | |||
| 10/29/2016 | Clemson | 37 | at | Florida State | 34 | |||
| Duke | 35 | at | Georgia Tech | 38 | ||||
| Boston College | 21 | at | North Carolina State | 14 | ||||
| Miami-Florida | 27 | at | Notre Dame | 30 | @ ND | |||
| Louisville | 32 | at | Virginia | 25 | ||||
| Army | 21 | at | Wake Forest | 13 | Ind | |||
| 11/5/2016 | Louisville | 52 | at | Boston College | 7 | |||
| Syracuse | 0 | at | Clemson | 54 | ||||
| Virginia Tech | 24 | at | Duke | 21 | ||||
| Pittsburgh | 28 | at | Miami-Florida | 51 | ||||
| Georgia Tech | 20 | at | North Carolina | 48 | ||||
| Florida State | 24 | at | North Carolina State | 20 | ||||
| Virginia | 20 | at | Wake Forest | 27 | ||||
| 11/10/2016 | North Carolina | 27 | at | Duke | 28 | |||
| 11/11/2016 | Boston College | 7 | at | Florida State | 45 | |||
| 11/12/2016 | Pittsburgh | 43 | at | Clemson | 42 | |||
| Wake Forest | 12 | at | Louisville | 44 | ||||
| North Carolina State | 35 | at | Syracuse | 20 | ||||
| Miami-Florida | 34 | at | Virginia | 14 | ||||
| Georgia Tech | 30 | at | Virginia Tech | 20 | ||||
| 11/17/2016 | Louisville | 10 | at | Houston | 36 | @ AAC | ||
| 11/19/2016 | Connecticut | 0 | at | Boston College | 30 | AAC | ||
| Virginia | 17 | at | Georgia Tech | 31 | ||||
| The Citadel | 7 | at | North Carolina | 41 | SoCon (1AA) | |||
| Miami-Florida | 27 | at | North Carolina State | 13 | ||||
| Virginia Tech | 34 | at | Notre Dame | 31 | @ ND | |||
| Duke | 14 | at | Pittsburgh | 56 | ||||
| Florida State | 45 | at | Syracuse | 14 | ||||
| Clemson | 35 | at | Wake Forest | 13 | ||||
| 11/25/2016 | North Carolina State | 28 | at | North Carolina | 21 | |||
| 11/26/2016 | South Carolina | 7 | at | Clemson | 56 | SEC | ||
| Florida | 13 | at | Florida State | 31 | SEC | |||
| Georgia Tech | 28 | at | Georgia | 27 | @ SEC | |||
| Kentucky | 41 | at | Louisville | 38 | SEC | |||
| Duke | 21 | at | Miami-Florida | 40 | ||||
| Syracuse | 61 | at | Pittsburgh | 76 | ||||
| Virginia | 10 | at | Virginia Tech | 52 | ||||
| Boston College | 17 | at | Wake Forest | 14 | ||||
| 12/3/2016 | Clemson | 42 | vs | Virginia Tech | 35 | Orlando FL | ||
| 12/26/2016 | Maryland | 30 | vs | Boston College | 36 | Quick Lane Bowl (Detroit MI) | vs B10 | |
| North Carolina State | 41 | vs | Vanderbilt | 17 | Independence Bowl (Shreveport LA) | vs SEC | ||
| 12/27/2016 | Temple | 26 | vs | Wake Forest | 34 | Military Bowl (Annapolis MD) | vs AAC | |
| 12/28/2016 | West Virginia | 14 | vs | Miami-Florida | 31 | Russell Athletic Bowl (Orlando FL) | vs B12 | |
| Pittsburgh | 24 | vs | Northwestern | 31 | Pinstripe Bowl (New York NY) | vs B10 | ||
| 12/29/2016 | Arkansas | 24 | vs | Virginia Tech | 35 | Belk Bowl (Charlotte NC) | vs SEC | |
| 12/30/2016 | Michigan | 32 | vs | Florida State | 33 | Orange Bowl (Miami FL) | vs B10 | |
| Stanford | 25 | vs | North Carolina | 23 | Sun Bowl (El Paso TX) | vs P12 | ||
| 12/31/2016 | Ohio State | 0 | vs | Clemson | 31 | Fiesta Bowl (Glendale AZ -1A Semifinal) | vs B10 | |
| Georgia Tech | 33 | vs | Kentucky | 18 | Taxslayer Bowl (Jacksonville FL) | vs SEC | ||
| LSU | 29 | vs | Louisville | 9 | Citrus Bowl (Orlando FL) | vs SEC | ||
| 1/9/2017 | Clemson | 35 | vs | Alabama | 31 | 1A Championship (Tampa FL) | vs SEC |