| 9/1/2016 | The Citadel (10-2,7-1) | 24 | at | Mercer | 23 | |||
| 9/10/2016 | Mercer | 10 | at | Georgia Tech (9-4) | 35 | at ACC | ||
| 9/17/2016 | Tennessee Tech (5-6) | 27 | at | Mercer | 34 | OVC | ||
| 10/1/2016 | Mercer | 33 | at | VMI (3-8,0-7) | 30 | OT | ||
| 10/8/2016 | Mercer | 31 | at | Chattanooga (9-4,5-2) | 52 | |||
| 10/15/2016 | Western Carolina (2-9,1-6) | 24 | at | Mercer | 38 | |||
| 10/22/2016 | Mercer | 41 | at | Austin Peay (0-11) | 34 | at OVC | ||
| 10/29/2016 | Mercer | 21 | at | Wofford (10-4,6-2) | 31 | |||
| 11/5/2016 | East Tennessee St (5-6) | 13 | at | Mercer | 21 | IndFCS | ||
| 11/12/2016 | Mercer | 19 | at | Samford (7-5,5-2) | 24 | |||
| 11/19/2016 | Furman (3-8,2-5) | 24 | at | Mercer | 27 |
| vs Mercer | vs Other Opponents | Mercer compared to OOs | |
| Record: | 5-6 | 58-61 | |
| Points Scored: | 28.91 | 26.27 | -2.64 |
| Points Allowed: | 27.09 | 27.12 | -0.03 |
| Margin: | 1.82 | -0.85 | -2.67 |
| Total Points: | 56.00 | 53.39 | 2.61 |