| 9/3/2016 | Murray State (4-7) | 3 | at | Illinois | 52 | OVC (1AA) | ||
| 9/10/2016 | North Carolina (8-5) | 48 | at | Illinois | 23 | ACC | ||
| 9/17/2016 | Western Michigan (13-1) | 34 | at | Illinois | 10 | MAC | ||
| 10/1/2016 | Illinois | 16 | at | Nebraska (9-4,6-3) | 31 | |||
| 10/8/2016 | Purdue (3-9,1-8) | 34 | at | Illinois | 31 | OT | ||
| 10/15/2016 | Illinois | 24 | at | Rutgers (2-10,0-9) | 7 | |||
| 10/22/2016 | Illinois | 8 | at | Michigan (10-3,7-2) | 41 | |||
| 10/29/2016 | Minnesota (9-4,5-4) | 40 | at | Illinois | 17 | |||
| 11/5/2016 | Michigan State (3-9,1-8) | 27 | at | Illinois | 31 | |||
| 11/12/2016 | Illinois | 3 | at | Wisconsin (11-3,7-3) | 48 | |||
| 11/19/2016 | Iowa (8-5,6-3) | 28 | at | Illinois | 0 | |||
| 11/26/2016 | Illinois | 21 | at | Northwestern (7-6,5-4) | 42 |
| vs Illinois | vs Other Opponents | Illinois compared to OOs | |
| Record: | 9-3 | 78-63 | |
| Points Scored: | 31.92 | 28.28 | -3.64 |
| Points Allowed: | 19.67 | 25.01 | -5.34 |
| Margin: | 12.25 | 3.27 | -8.98 |
| Total Points: | 51.59 | 53.29 | -1.70 |