| 9/3/2016 | Oklahoma (11-2) | 23 | at | Houston | 33 | B12 | ||
| 9/10/2016 | Lamar (3-8) | 0 | at | Houston | 42 | SLC (1AA) | ||
| 9/15/2016 | Houston | 40 | at | Cincinnati (4-8,1-7) | 16 | |||
| 9/24/2016 | Houston | 64 | at | Texas State (2-10) | 3 | at SBC | ||
| 9/29/2016 | Connecticut (3-9,1-7) | 14 | at | Houston | 42 | |||
| 10/8/2016 | Houston | 40 | at | Navy (9-5,7-2) | 46 | |||
| 10/15/2016 | Tulsa (10-3,6-2) | 31 | at | Houston | 38 | |||
| 10/22/2016 | Houston | 16 | at | SMU (5-7,3-5) | 38 | |||
| 10/29/2016 | UCF (6-7,4-4) | 24 | at | Houston | 31 | |||
| 11/12/2016 | Tulane (4-8,1-7) | 18 | at | Houston | 30 | |||
| 11/17/2016 | Louisville (9-4) | 10 | at | Houston | 36 | ACC | ||
| 11/25/2016 | Houston | 44 | at | Memphis (8-5,5-3) | 48 | |||
| 12/17/2016 | Houston | 10 | vs | San Diego State (11-3) | 34 | Las Vegas Bowl | vs MW |
| vs Houston | vs Other Opponents | Houston compared to OOs | |
| Record: | 4-9 | 81-70 | |
| Points Scored: | 23.46 | 31.51 | 8.05 |
| Points Allowed: | 35.85 | 28.30 | 7.55 |
| Margin: | -12.39 | 3.21 | 15.60 |
| Total Points: | 59.31 | 59.81 | -0.50 |