| 8/27/2016 | Charleston Southern | 17 | at | North Dakota State (12-2) | 24 | at MVC | ||
| 9/3/2016 | Kentucky State (4-7) | 7 | at | Charleston Southern | 57 | SIAC (D2) | ||
| 9/10/2016 | Charleston Southern | 8 | at | Florida State (10-3) | 52 | at ACC | ||
| 9/24/2016 | Charleston Southern | 35 | at | Monmouth NJ (4-7,0-5) | 7 | |||
| 10/1/2016 | Charleston Southern | 59 | at | Coastal Carolina (10-2) | 58 | 2OT | at IndFCS | |
| 10/22/2016 | Presbyterian (2-9,1-4) | 3 | at | Charleston Southern | 38 | |||
| 10/29/2016 | Bucknell (4-7) | 28 | at | Charleston Southern | 49 | Pat | ||
| 11/5/2016 | Gardner-Webb (5-6,3-2) | 17 | at | Charleston Southern | 10 | |||
| 11/12/2016 | Charleston Southern | 48 | at | Liberty (6-5,4-1) | 26 | |||
| 11/19/2016 | Kennesaw St (8-3,3-2) | 7 | at | Charleston Southern | 28 | |||
| 11/26/2016 | Charleston Southern | 14 | at | Wofford (10-4) | 15 | at SoCon |
| vs Charleston Southern | vs Other Opponents | Charleston Southern compared to OOs | |
| Record: | 4-7 | 71-48 | |
| Points Scored: | 22.18 | 27.33 | 5.15 |
| Points Allowed: | 33.00 | 22.76 | 10.24 |
| Margin: | -10.82 | 4.57 | 15.39 |
| Total Points: | 55.18 | 50.09 | 5.09 |