| 9/3/2016 | Hawaii (7-7) | 3 | at | Michigan | 63 | MW | ||
| 9/10/2016 | UCF (6-7) | 14 | at | Michigan | 51 | AAC | ||
| 9/17/2016 | Colorado (10-4) | 28 | at | Michigan | 45 | P12 | ||
| 9/24/2016 | Penn State (11-3,9-1) | 10 | at | Michigan | 49 | |||
| 10/1/2016 | Wisconsin (11-3,7-3) | 7 | at | Michigan | 14 | |||
| 10/8/2016 | Michigan | 78 | at | Rutgers (2-10,0-9) | 0 | |||
| 10/22/2016 | Illinois (3-9,2-7) | 8 | at | Michigan | 41 | |||
| 10/29/2016 | Michigan | 32 | at | Michigan State (3-9,1-8) | 23 | |||
| 11/5/2016 | Maryland (6-7,3-6) | 3 | at | Michigan | 59 | |||
| 11/12/2016 | Michigan | 13 | at | Iowa (8-5,6-3) | 14 | |||
| 11/19/2016 | Indiana (6-7,4-5) | 10 | at | Michigan | 20 | |||
| 11/26/2016 | Michigan | 27 | at | Ohio State (11-2,8-1) | 30 | 2OT | ||
| 12/30/2016 | Michigan | 32 | vs | Florida State (10-3) | 33 | Orange Bowl (Miami FL) | vs ACC |
| vs Michigan | vs Other Opponents | Michigan compared to OOs | |
| Record: | 3-10 | 91-66 | |
| Points Scored: | 14.08 | 29.43 | 15.35 |
| Points Allowed: | 40.31 | 24.66 | 15.65 |
| Margin: | -26.23 | 4.77 | 31.00 |
| Total Points: | 54.39 | 54.09 | 0.30 |