| 9/1/2016 | Appalachian State (10-3) | 13 | at | Tennessee | 20 | OT | SBC | |
| 9/10/2016 | Virginia Tech (10-4) | 24 | vs | Tennessee | 45 | Bristol TN | ACC | |
| 9/17/2016 | Ohio (8-6) | 19 | at | Tennessee | 28 | MAC | ||
| 9/24/2016 | Florida (9-4,6-3) | 28 | at | Tennessee | 38 | |||
| 10/1/2016 | Tennessee | 34 | at | Georgia (8-5,4-4) | 31 | |||
| 10/8/2016 | Tennessee | 38 | at | Texas A&M (8-5,4-4) | 45 | 2OT | ||
| 10/15/2016 | Alabama (14-1,9-0) | 49 | at | Tennessee | 10 | |||
| 10/29/2016 | Tennessee | 21 | at | South Carolina (6-7,3-5) | 24 | |||
| 11/5/2016 | Tennessee Tech (5-6) | 0 | at | Tennessee | 55 | OVC (1AA) | ||
| 11/12/2016 | Kentucky (7-6,4-4) | 36 | at | Tennessee | 49 | |||
| 11/19/2016 | Missouri (4-8,2-6) | 37 | at | Tennessee | 63 | |||
| 11/26/2016 | Tennessee | 34 | at | Vanderbilt (6-7,3-5) | 45 | |||
| 12/30/2016 | Nebraska (9-4) | 24 | vs | Tennessee | 38 | Music City Bowl (Nashville TN) | B10 |
| vs Tennessee | vs Other Opponents | Tennessee compared to OOs | |
| Record: | 4-9 | 100-57 | |
| Points Scored: | 28.85 | 28.69 | -0.16 |
| Points Allowed: | 36.38 | 22.34 | 14.04 |
| Margin: | -7.53 | 6.35 | 13.88 |
| Total Points: | 65.23 | 51.03 | 14.20 |