| 9/4/2016 | Notre Dame | 47 | at | Texas (5-7) | 50 | 2OT | at B12 | |
| 9/10/2016 | Nevada (5-7) | 10 | at | Notre Dame | 39 | MW | ||
| 9/17/2016 | Michigan State (3-9) | 36 | at | Notre Dame | 28 | B10 | ||
| 9/24/2016 | Duke (4-8) | 38 | at | Notre Dame | 35 | ACC | ||
| 10/1/2016 | Notre Dame | 50 | vs | Syracuse (4-8) | 33 | East Rutherford NJ | vs ACC | |
| 10/8/2016 | Notre Dame | 3 | at | North Carolina State (7-6) | 10 | at ACC | ||
| 10/15/2016 | Stanford (10-3) | 17 | at | Notre Dame | 10 | P12 | ||
| 10/29/2016 | Miami-Florida (9-4) | 27 | at | Notre Dame | 30 | ACC | ||
| 11/5/2016 | Notre Dame | 27 | vs | Navy (9-5) | 28 | Jacksonville FL | vs AAC | |
| 11/12/2016 | Army (8-5) | 6 | vs | Notre Dame | 44 | San Antonio TX | Ind | |
| 11/19/2016 | Virginia Tech (10-4) | 34 | at | Notre Dame | 31 | ACC | ||
| 11/26/2016 | Notre Dame | 27 | at | Southern California (10-3) | 45 | at P12 |
| vs Notre Dame | vs Other Opponents | Notre Dame compared to OOs | |
| Record: | 8-4 | 76-65 | |
| Points Scored: | 27.83 | 29.98 | 2.15 |
| Points Allowed: | 30.92 | 25.65 | 5.27 |
| Margin: | -3.09 | 4.33 | 7.42 |
| Total Points: | 58.75 | 55.63 | 3.12 |