| 9/3/2016 | Southeastern Louisiana (7-4) | 7 | at | Oklahoma State | 61 | SLC (1AA) | ||
| 9/10/2016 | Central Michigan (6-7) | 30 | at | Oklahoma State | 27 | MAC | ||
| 9/17/2016 | Pittsburgh (8-5) | 38 | at | Oklahoma State | 45 | ACC | ||
| 9/24/2016 | Oklahoma State | 24 | at | Baylor (7-6,3-6) | 35 | |||
| 10/1/2016 | Texas (5-7,3-6) | 31 | at | Oklahoma State | 49 | |||
| 10/8/2016 | Iowa State (3-9,2-7) | 31 | at | Oklahoma State | 38 | |||
| 10/22/2016 | Oklahoma State | 44 | at | Kansas (2-10,1-8) | 20 | |||
| 10/29/2016 | West Virginia (10-3,7-2) | 20 | at | Oklahoma State | 37 | |||
| 11/5/2016 | Oklahoma State | 43 | at | Kansas State (9-4,6-3) | 37 | |||
| 11/12/2016 | Texas Tech (5-7,3-6) | 44 | at | Oklahoma State | 45 | |||
| 11/19/2016 | Oklahoma State | 31 | at | TCU (6-7,4-5) | 6 | |||
| 12/3/2016 | Oklahoma State | 20 | at | Oklahoma (11-2,9-0) | 38 | |||
| 12/29/2016 | Oklahoma State | 38 | vs | Colorado (10-4) | 8 | Alamo Bowl (San Antonio TX) | vs P12 |
| vs Oklahoma State | vs Other Opponents | Oklahoma State compared to OOs | |
| Record: | 3-10 | 86-65 | |
| Points Scored: | 26.54 | 33.20 | 6.66 |
| Points Allowed: | 38.62 | 29.30 | 9.32 |
| Margin: | -12.08 | 3.90 | 15.98 |
| Total Points: | 65.16 | 62.50 | 2.66 |