| 9/2/2016 | Albany NY (7-4) | 22 | at | Buffalo | 16 | CAAF (1AA) | ||
| 9/17/2016 | Buffalo | 14 | at | Nevada (5-7) | 38 | at MW | ||
| 9/24/2016 | Army (8-5) | 20 | at | Buffalo | 23 | OT | Ind | |
| 10/1/2016 | Buffalo | 3 | at | Boston College (7-6) | 35 | at ACC | ||
| 10/8/2016 | Kent State (3-9,2-6) | 44 | at | Buffalo | 20 | |||
| 10/15/2016 | Ball State (4-8,1-7) | 31 | at | Buffalo | 21 | |||
| 10/22/2016 | Buffalo | 7 | at | Northern Illinois (5-7,5-3) | 44 | |||
| 10/27/2016 | Akron (5-7,3-5) | 20 | at | Buffalo | 41 | |||
| 11/3/2016 | Buffalo | 10 | at | Ohio (8-6,6-3) | 34 | |||
| 11/12/2016 | Miami-Ohio (6-7,6-2) | 35 | at | Buffalo | 24 | |||
| 11/19/2016 | Buffalo | 0 | at | Western Michigan (13-1,9-0) | 38 | |||
| 11/25/2016 | Buffalo | 19 | at | Bowling Green (4-8,3-5) | 27 |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 10-2 | 65-73 | |
| Points Scored: | 32.33 | 26.49 | -5.84 |
| Points Allowed: | 16.50 | 27.36 | -10.86 |
| Margin: | 15.83 | -0.87 | -16.70 |
| Total Points: | 48.83 | 53.85 | -5.02 |