| 9/3/2016 | Southern Miss (7-6) | 44 | at | Kentucky | 35 | CUSA | ||
| 9/10/2016 | Kentucky | 7 | at | Florida (9-4,6-3) | 45 | |||
| 9/17/2016 | New Mexico State (3-9) | 42 | at | Kentucky | 62 | SBC | ||
| 9/24/2016 | South Carolina (6-7,3-5) | 10 | at | Kentucky | 17 | |||
| 10/1/2016 | Kentucky | 6 | at | Alabama (14-1,9-0) | 34 | |||
| 10/8/2016 | Vanderbilt (6-7,3-5) | 13 | at | Kentucky | 20 | |||
| 10/22/2016 | Mississippi State (6-7,3-5) | 38 | at | Kentucky | 40 | |||
| 10/29/2016 | Kentucky | 35 | at | Missouri (4-8,2-6) | 21 | |||
| 11/5/2016 | Georgia (8-5,4-4) | 27 | at | Kentucky | 24 | |||
| 11/12/2016 | Kentucky | 36 | at | Tennessee (9-4,4-4) | 49 | |||
| 11/19/2016 | Austin Peay (0-11) | 13 | at | Kentucky | 49 | OVC (1AA) | ||
| 11/26/2016 | Kentucky | 41 | at | Louisville (9-4) | 38 | at ACC | ||
| 12/31/2016 | Georgia Tech (9-4) | 33 | vs | Kentucky | 18 | Taxslayer Bowl (Jacksonville FL) | ACC |
| vs Kentucky | vs Other Opponents | Kentucky compared to OOs | |
| Record: | 6-7 | 84-70 | |
| Points Scored: | 31.31 | 29.37 | -1.94 |
| Points Allowed: | 30.00 | 26.95 | 3.05 |
| Margin: | 1.31 | 2.42 | 1.11 |
| Total Points: | 61.31 | 56.32 | 4.99 |