| 9/3/2016 | South Carolina State | 0 | at | UCF (6-7) | 38 | at AAC | ||
| 9/10/2016 | South Carolina State | 24 | at | Louisiana Tech (9-5) | 53 | at CUSA | ||
| 9/17/2016 | South Carolina State | 0 | at | Clemson (14-1) | 59 | at ACC | ||
| 9/24/2016 | South Carolina State | 48 | at | Florida A&M (4-7,4-4) | 14 | |||
| 10/15/2016 | South Carolina State | 14 | at | Howard (2-9,2-6) | 9 | |||
| 10/22/2016 | Delaware State (0-11,0-8) | 3 | at | South Carolina State | 30 | |||
| 10/29/2016 | South Carolina State | 26 | at | Hampton (5-6,5-3) | 28 | |||
| 11/5/2016 | South Carolina State | 20 | at | North Carolina A&T (9-3,7-1) | 30 | |||
| 11/12/2016 | Norfolk State (4-7,3-5) | 13 | at | South Carolina State | 10 | |||
| 11/19/2016 | Savannah State (3-7,3-5) | 0 | at | South Carolina State | 32 | |||
| 11/26/2016 | Bethune-Cookman (4-6,4-4) | 7 | at | South Carolina State | 28 |
| vs South Carolina State | vs Other Opponents | South Carolina State compared to OOs | |
| Record: | 6-5 | 54-64 | |
| Points Scored: | 23.09 | 26.34 | 3.25 |
| Points Allowed: | 21.09 | 28.68 | -7.59 |
| Margin: | 2.00 | -2.34 | -4.34 |
| Total Points: | 44.18 | 55.02 | -10.84 |