| 9/3/2016 | Bowling Green (4-8) | 10 | at | Ohio State | 77 | MAC | ||
| 9/10/2016 | Tulsa (10-3) | 3 | at | Ohio State | 48 | AAC | ||
| 9/17/2016 | Ohio State | 45 | at | Oklahoma (11-2) | 24 | at B12 | ||
| 10/1/2016 | Rutgers (2-10,0-9) | 0 | at | Ohio State | 58 | |||
| 10/8/2016 | Indiana (6-7,4-5) | 17 | at | Ohio State | 38 | |||
| 10/15/2016 | Ohio State | 30 | at | Wisconsin (11-3,7-3) | 23 | OT | ||
| 10/22/2016 | Ohio State | 21 | at | Penn State (11-3,9-1) | 24 | |||
| 10/29/2016 | Northwestern (7-6,5-4) | 20 | at | Ohio State | 24 | |||
| 11/5/2016 | Nebraska (9-4,6-3) | 3 | at | Ohio State | 62 | |||
| 11/12/2016 | Ohio State | 62 | at | Maryland (6-7,3-6) | 3 | |||
| 11/19/2016 | Ohio State | 17 | at | Michigan State (3-9,1-8) | 16 | |||
| 11/26/2016 | Michigan (10-3,7-2) | 27 | at | Ohio State | 30 | 2OT | ||
| 12/31/2016 | Ohio State | 0 | vs | Clemson (14-1) | 31 | Fiesta Bowl (Glendale AZ -1A Semifinal) | vs ACC |
| vs Ohio State | vs Other Opponents | Ohio State compared to OOs | |
| Record: | 2-11 | 102-55 | |
| Points Scored: | 15.46 | 32.39 | 16.93 |
| Points Allowed: | 39.38 | 24.58 | 14.80 |
| Margin: | -23.92 | 7.81 | 31.73 |
| Total Points: | 54.84 | 56.97 | -2.13 |