| 9/3/2016 | Western Michigan (13-1) | 22 | at | Northwestern | 21 | MAC | ||
| 9/10/2016 | Illinois State (6-6) | 9 | at | Northwestern | 7 | MVC (1AA) | ||
| 9/17/2016 | Duke (4-8) | 13 | at | Northwestern | 24 | ACC | ||
| 9/24/2016 | Nebraska (9-4,6-3) | 24 | at | Northwestern | 13 | |||
| 10/1/2016 | Northwestern | 38 | at | Iowa (8-5,6-3) | 31 | |||
| 10/15/2016 | Northwestern | 54 | at | Michigan State (3-9,1-8) | 40 | |||
| 10/22/2016 | Indiana (6-7,4-5) | 14 | at | Northwestern | 24 | |||
| 10/29/2016 | Northwestern | 20 | at | Ohio State (11-2,8-1) | 24 | |||
| 11/5/2016 | Wisconsin (11-3,7-3) | 21 | at | Northwestern | 7 | |||
| 11/12/2016 | Northwestern | 45 | at | Purdue (3-9,1-8) | 17 | |||
| 11/19/2016 | Northwestern | 12 | at | Minnesota (9-4,5-4) | 29 | |||
| 11/26/2016 | Illinois (3-9,2-7) | 21 | at | Northwestern | 42 | |||
| 12/28/2016 | Pittsburgh (8-5) | 24 | vs | Northwestern | 31 | Pinstripe Bowl (New York NY) | ACC |
| vs Northwestern | vs Other Opponents | Northwestern compared to OOs | |
| Record: | 6-7 | 88-65 | |
| Points Scored: | 22.23 | 29.61 | 7.38 |
| Points Allowed: | 26.00 | 24.76 | 1.24 |
| Margin: | -3.77 | 4.85 | 8.62 |
| Total Points: | 48.23 | 54.37 | -6.14 |