| 9/4/2016 | Hampton (5-6) | 21 | at | Old Dominion | 54 | MEAC (1AA) | ||
| 9/10/2016 | Old Dominion | 7 | at | Appalachian State (10-3) | 31 | at SBC | ||
| 9/17/2016 | Old Dominion | 22 | at | North Carolina State (7-6) | 49 | at ACC | ||
| 9/24/2016 | Texas-San Antonio (6-7,5-3) | 19 | at | Old Dominion | 33 | |||
| 10/1/2016 | Old Dominion | 52 | at | UNC-Charlotte (4-8,3-5) | 17 | |||
| 10/7/2016 | Massachusetts (2-10) | 16 | at | Old Dominion | 36 | MAC | ||
| 10/22/2016 | Old Dominion | 24 | at | Western Kentucky (11-3,8-1) | 59 | |||
| 10/29/2016 | Old Dominion | 31 | at | UTEP (4-8,2-6) | 21 | |||
| 11/5/2016 | Marshall (3-9,2-6) | 14 | at | Old Dominion | 38 | |||
| 11/12/2016 | Southern Miss (7-6,4-4) | 35 | at | Old Dominion | 51 | |||
| 11/19/2016 | Old Dominion | 42 | at | Florida Atlantic (3-9,2-6) | 24 | |||
| 11/26/2016 | Florida Intl (4-8,4-4) | 28 | at | Old Dominion | 42 | |||
| 12/23/2016 | Eastern Michigan (7-6) | 20 | vs | Old Dominion | 24 | Popeyes Bahama Bowl (Nassau) | MAC |
| vs Old Dominion | vs Other Opponents | Old Dominion compared to OOs | |
| Record: | 3-10 | 70-79 | |
| Points Scored: | 27.23 | 28.44 | 1.21 |
| Points Allowed: | 35.08 | 29.52 | 5.56 |
| Margin: | -7.85 | -1.08 | 6.77 |
| Total Points: | 62.31 | 57.96 | 4.35 |