| 9/3/2016 | Towson (4-7) | 20 | at | South Florida | 56 | CAAF (1AA) | ||
| 9/10/2016 | Northern Illinois (5-7) | 17 | at | South Florida | 48 | MAC | ||
| 9/17/2016 | South Florida | 45 | at | Syracuse (4-8) | 20 | at ACC | ||
| 9/24/2016 | Florida State (10-3) | 55 | at | South Florida | 35 | ACC | ||
| 10/1/2016 | South Florida | 45 | at | Cincinnati (4-8,1-7) | 20 | |||
| 10/8/2016 | East Carolina (3-9,1-7) | 22 | at | South Florida | 38 | |||
| 10/15/2016 | Connecticut (3-9,1-7) | 27 | at | South Florida | 42 | |||
| 10/21/2016 | South Florida | 30 | at | Temple (10-4,8-1) | 46 | |||
| 10/28/2016 | Navy (9-5,7-2) | 45 | at | South Florida | 52 | |||
| 11/12/2016 | South Florida | 49 | at | Memphis (8-5,5-3) | 42 | |||
| 11/19/2016 | South Florida | 35 | at | SMU (5-7,3-5) | 27 | |||
| 11/26/2016 | UCF (6-7,4-4) | 31 | at | South Florida | 48 | |||
| 12/29/2016 | South Florida | 46 | vs | South Carolina (6-7) | 39 | OT | Birmingham Bowl | vs SEC |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 2-11 | 75-75 | |
| Points Scored: | 31.62 | 27.74 | -3.88 |
| Points Allowed: | 43.77 | 27.64 | 16.13 |
| Margin: | -12.15 | 0.10 | 12.25 |
| Total Points: | 75.39 | 55.38 | 20.01 |