| 9/1/2016 | Presbyterian (2-9) | 3 | at | Central Michigan | 49 | BigS (1AA) | ||
| 9/10/2016 | Central Michigan | 30 | at | Oklahoma State (10-3) | 27 | at B12 | ||
| 9/17/2016 | UNLV (4-8) | 21 | at | Central Michigan | 44 | MW | ||
| 9/24/2016 | Central Michigan | 35 | at | Virginia (2-10) | 49 | at ACC | ||
| 10/1/2016 | Western Michigan (13-1,9-0) | 49 | at | Central Michigan | 10 | |||
| 10/8/2016 | Ball State (4-8,1-7) | 21 | at | Central Michigan | 24 | |||
| 10/15/2016 | Central Michigan | 34 | at | Northern Illinois (5-7,5-3) | 28 | 3OT | ||
| 10/22/2016 | Central Michigan | 17 | at | Toledo (9-4,6-2) | 31 | |||
| 10/29/2016 | Kent State (3-9,2-6) | 27 | at | Central Michigan | 24 | |||
| 11/4/2016 | Central Michigan | 17 | at | Miami-Ohio (6-7,6-2) | 37 | |||
| 11/15/2016 | Ohio (8-6,6-3) | 20 | at | Central Michigan | 27 | |||
| 11/22/2016 | Central Michigan | 21 | at | Eastern Michigan (7-6,4-4) | 26 | |||
| 12/19/2016 | Central Michigan | 10 | vs | Tulsa (10-3) | 55 | Miami Beach Bowl | vs AAC |
| vs Central Michigan | vs Other Opponents | Central Michigan compared to OOs | |
| Record: | 7-6 | 76-75 | |
| Points Scored: | 30.31 | 29.60 | -0.71 |
| Points Allowed: | 26.31 | 28.28 | -1.97 |
| Margin: | 4.00 | 1.32 | -2.68 |
| Total Points: | 56.62 | 57.88 | -1.26 |