| 9/3/2016 | Missouri (4-8) | 11 | at | West Virginia | 26 | SEC | ||
| 9/10/2016 | Youngstown State (12-4) | 21 | at | West Virginia | 38 | MVC (1AA) | ||
| 9/24/2016 | BYU (9-4) | 32 | vs | West Virginia | 35 | Landover MD | Ind | |
| 10/1/2016 | Kansas State (9-4,6-3) | 16 | at | West Virginia | 17 | |||
| 10/15/2016 | West Virginia | 48 | at | Texas Tech (5-7,3-6) | 17 | |||
| 10/22/2016 | TCU (6-7,4-5) | 10 | at | West Virginia | 34 | |||
| 10/29/2016 | West Virginia | 20 | at | Oklahoma State (10-3,7-2) | 37 | |||
| 11/5/2016 | Kansas (2-10,1-8) | 21 | at | West Virginia | 48 | |||
| 11/12/2016 | West Virginia | 24 | at | Texas (5-7,3-6) | 20 | |||
| 11/19/2016 | Oklahoma (11-2,9-0) | 56 | at | West Virginia | 28 | |||
| 11/26/2016 | West Virginia | 49 | at | Iowa State (3-9,2-7) | 19 | |||
| 12/3/2016 | Baylor (7-6,3-6) | 21 | at | West Virginia | 24 | |||
| 12/28/2016 | West Virginia | 14 | vs | Miami-Florida (9-4) | 31 | Russell Athletic Bowl (Orlando FL) | vs ACC |
| vs West Virginia | vs Other Opponents | West Virginia compared to OOs | |
| Record: | 3-10 | 89-65 | |
| Points Scored: | 24.00 | 33.53 | 9.53 |
| Points Allowed: | 31.15 | 27.68 | 3.47 |
| Margin: | -7.15 | 5.85 | 13.00 |
| Total Points: | 55.15 | 61.21 | -6.06 |