| 9/1/2016 | Appalachian State | 13 | at | Tennessee (9-4) | 20 | OT | at SEC | |
| 9/10/2016 | Old Dominion (10-3) | 7 | at | Appalachian State | 31 | CUSA | ||
| 9/17/2016 | Miami-Florida (9-4) | 45 | at | Appalachian State | 10 | ACC | ||
| 9/24/2016 | Appalachian State | 45 | at | Akron (5-7) | 38 | at MAC | ||
| 10/1/2016 | Georgia State (3-9,2-6) | 3 | at | Appalachian State | 17 | |||
| 10/12/2016 | Appalachian State | 24 | at | UL Lafayette (6-7,5-3) | 0 | |||
| 10/22/2016 | Idaho (9-4,6-2) | 19 | at | Appalachian State | 37 | |||
| 10/27/2016 | Appalachian State | 34 | at | Georgia Southern (5-7,4-4) | 10 | |||
| 11/5/2016 | Texas State (2-10,0-8) | 10 | at | Appalachian State | 35 | |||
| 11/12/2016 | Appalachian State | 24 | at | Troy (10-3,6-2) | 28 | |||
| 11/19/2016 | UL Monroe (4-8,3-5) | 17 | at | Appalachian State | 42 | |||
| 11/26/2016 | Appalachian State | 37 | at | New Mexico State (3-9,2-6) | 7 | |||
| 12/17/2016 | Appalachian State | 31 | vs | Toledo (9-4) | 28 | Camellia Bowl (Montgomery AL) | vs MAC |
| vs Appalachian State | vs Other Opponents | Appalachian State compared to OOs | |
| Record: | 3-10 | 81-69 | |
| Points Scored: | 17.85 | 29.80 | 11.95 |
| Points Allowed: | 29.23 | 29.43 | -0.20 |
| Margin: | -11.38 | 0.37 | 11.75 |
| Total Points: | 47.08 | 59.23 | -12.15 |