| 9/3/2016 | Massachusetts | 7 | at | Florida (9-4) | 24 | at SEC | ||
| 9/10/2016 | Boston College (7-6) | 26 | vs | Massachusetts | 7 | Foxboro MA | ACC | |
| 9/17/2016 | Florida Intl (4-8) | 13 | at | Massachusetts | 21 | CUSA | ||
| 9/24/2016 | Mississippi State (6-7) | 47 | vs | Massachusetts | 35 | Foxboro MA | SEC | |
| 10/1/2016 | Tulane (4-8) | 31 | at | Massachusetts | 24 | AAC | ||
| 10/7/2016 | Massachusetts | 16 | at | Old Dominion (10-3) | 36 | at CUSA | ||
| 10/15/2016 | Louisiana Tech (9-5) | 56 | vs | Massachusetts | 28 | Foxboro MA | CUSA | |
| 10/22/2016 | Massachusetts | 28 | at | South Carolina (6-7) | 34 | at SEC | ||
| 10/29/2016 | Wagner (6-5) | 10 | at | Massachusetts | 34 | NE (1AA) | ||
| 11/5/2016 | Massachusetts | 31 | at | Troy (10-3) | 52 | at SBC | ||
| 11/19/2016 | Massachusetts | 9 | at | BYU (9-4) | 51 | at Ind | ||
| 11/26/2016 | Massachusetts | 40 | at | Hawaii (7-7) | 46 | at MW |
| vs Massachusetts | vs Other Opponents | Massachusetts compared to OOs | |
| Record: | 10-2 | 77-65 | |
| Points Scored: | 35.50 | 27.98 | -7.52 |
| Points Allowed: | 23.33 | 27.39 | -4.06 |
| Margin: | 12.17 | 0.59 | -11.58 |
| Total Points: | 58.83 | 55.37 | 3.46 |