| 9/5/2016 | Mississippi | 34 | vs | Florida State (10-3) | 45 | Orlando FL | vs ACC | |
| 9/10/2016 | Wofford (10-4) | 13 | at | Mississippi | 38 | SoCon (1AA) | ||
| 9/17/2016 | Alabama (14-1,9-0) | 48 | at | Mississippi | 43 | |||
| 9/24/2016 | Georgia (8-5,4-4) | 14 | at | Mississippi | 45 | |||
| 10/1/2016 | Memphis (8-5) | 28 | at | Mississippi | 48 | AAC | ||
| 10/15/2016 | Mississippi | 30 | at | Arkansas (7-6,3-5) | 34 | |||
| 10/22/2016 | Mississippi | 21 | at | LSU (8-4,5-3) | 38 | |||
| 10/29/2016 | Auburn (8-5,5-3) | 40 | at | Mississippi | 29 | |||
| 11/5/2016 | Georgia Southern (5-7) | 27 | at | Mississippi | 37 | SBC | ||
| 11/12/2016 | Mississippi | 29 | at | Texas A&M (8-5,4-4) | 28 | |||
| 11/19/2016 | Mississippi | 17 | at | Vanderbilt (6-7,3-5) | 38 | |||
| 11/26/2016 | Mississippi State (6-7,3-5) | 55 | at | Mississippi | 20 |
| vs Mississippi | vs Other Opponents | Mississippi compared to OOs | |
| Record: | 7-5 | 91-54 | |
| Points Scored: | 34.00 | 30.59 | -3.41 |
| Points Allowed: | 32.58 | 22.29 | 10.29 |
| Margin: | 1.42 | 8.30 | 6.88 |
| Total Points: | 66.58 | 52.88 | 13.70 |