| 9/3/2016 | Kent State (3-9) | 13 | at | Penn State | 33 | MAC | ||
| 9/10/2016 | Penn State | 39 | at | Pittsburgh (8-5) | 42 | at ACC | ||
| 9/17/2016 | Temple (10-4) | 27 | at | Penn State | 34 | AAC | ||
| 9/24/2016 | Penn State | 10 | at | Michigan (10-3,7-2) | 49 | |||
| 10/1/2016 | Minnesota (9-4,5-4) | 26 | at | Penn State | 29 | OT | ||
| 10/8/2016 | Maryland (6-7,3-6) | 14 | at | Penn State | 38 | |||
| 10/22/2016 | Ohio State (11-2,8-1) | 21 | at | Penn State | 24 | |||
| 10/29/2016 | Penn State | 62 | at | Purdue (3-9,1-8) | 24 | |||
| 11/5/2016 | Iowa (8-5,6-3) | 14 | at | Penn State | 41 | |||
| 11/12/2016 | Penn State | 45 | at | Indiana (6-7,4-5) | 31 | |||
| 11/19/2016 | Penn State | 39 | at | Rutgers (2-10,0-9) | 0 | |||
| 11/26/2016 | Michigan State (3-9,1-8) | 12 | at | Penn State | 45 | |||
| 12/3/2016 | Wisconsin (11-3,7-3) | 31 | vs | Penn State | 38 | Indianapolis IN | ||
| 1/2/2017 | Southern California (10-3) | 52 | vs | Penn State | 49 | Rose Bowl (Pasadena CA) | P12 |
| vs Penn State | vs Other Opponents | Penn State compared to OOs | |
| Record: | 3-11 | 97-69 | |
| Points Scored: | 25.43 | 29.54 | 4.11 |
| Points Allowed: | 37.57 | 23.87 | 13.70 |
| Margin: | -12.14 | 5.67 | 17.81 |
| Total Points: | 63.00 | 53.41 | 9.59 |