| 9/1/2016 | South Carolina | 13 | at | Vanderbilt (6-7,3-5) | 10 | |||
| 9/10/2016 | South Carolina | 14 | at | Mississippi State (6-7,3-5) | 27 | |||
| 9/17/2016 | East Carolina (3-9) | 15 | at | South Carolina | 20 | AAC | ||
| 9/24/2016 | South Carolina | 10 | at | Kentucky (7-6,4-4) | 17 | |||
| 10/1/2016 | Texas A&M (8-5,4-4) | 24 | at | South Carolina | 13 | |||
| 10/9/2016 | Georgia (8-5,4-4) | 28 | at | South Carolina | 14 | |||
| 10/22/2016 | Massachusetts (2-10) | 28 | at | South Carolina | 34 | MAC | ||
| 10/29/2016 | Tennessee (9-4,4-4) | 21 | at | South Carolina | 24 | |||
| 11/5/2016 | Missouri (4-8,2-6) | 21 | at | South Carolina | 31 | |||
| 11/12/2016 | South Carolina | 7 | at | Florida (9-4,6-3) | 20 | |||
| 11/19/2016 | Western Carolina (2-9) | 31 | at | South Carolina | 44 | SoCon (1AA) | ||
| 11/26/2016 | South Carolina | 7 | at | Clemson (14-1) | 56 | at ACC | ||
| 12/29/2016 | South Florida (11-2) | 46 | vs | South Carolina | 39 | OT | Birmingham Bowl | AAC |
| vs South Carolina | vs Other Opponents | South Carolina compared to OOs | |
| Record: | 7-6 | 82-71 | |
| Points Scored: | 26.46 | 30.71 | 4.25 |
| Points Allowed: | 20.77 | 28.76 | -7.99 |
| Margin: | 5.69 | 1.95 | -3.74 |
| Total Points: | 47.23 | 59.47 | -12.24 |