| Thursday, 23 Oct 2008 |
| MW | New Mexico | 10 | @ | Air Force | 23 | | |
| Mercyhurst (D2) | 24 | @ | Edinboro (D2) | 21 | | |
| MSC | Union KY (NAIA) | 27 | @ | Shorter (NAIA) | 33 | | |
| OVC | Jacksonville St | 30 | @ | Tennessee-Martin | 31 | | |
| Auburn | 17 | @ | West Virginia | 34 | | |
| Friday, 24 Oct 2008 |
| WAC | #10 Boise St | 33 | @ | San Jose St | 16 | | |
| MidAC | FDU-Florham (D3) | 7 | @ | Widener (D3) | 27 | | |
| Saturday, 25 Oct 2008 |
| LSC | Tarleton St (D2) | 17 | @ | Abilene Christian (D2) | 37 | | |
| RMAC | Mesa St (D2) | 27 | @ | Adams St (D2) | 30 | | |
| MIAA | Hope (D3) | 3 | @ | Adrian (D3) | 39 | | |
| SWAC | Alabama A&M | 17 | vs | Alabama St | 16 | | Birmingham AL |
| NE | St Francis PA | 3 | @ | Albany NY | 27 | | |
| MidAC | Wilkes (D3) | 10 | @ | Albright (D3) | 17 | | |
| SWAC | Texas Southern | 30 | @ | Alcorn St | 29 | | |
| NCA | Kenyon (D3) | 22 | @ | Allegheny (D3) | 27 | | |
| NESCAA | Tufts (D3) | 17 | @ | Amherst (D3) | 24 | | |
| LSC | West Texas A&M (D2) | 27 | @ | Angelo St (D2) | 0 | | |
| SoCon | Furman | 14 | @ | Appalachian St | 26 | | |
| P10 | #4 Southern Cal | 17 | @ | Arizona | 10 | | |
| P10 | #24 Oregon | 54 | @ | Arizona St | 20 | | |
| SEC | Mississippi | 23 | @ | Arkansas | 21 | | |
| GSC | Henderson St (D2) | 29 | @ | Arkansas Tech (D2) | 21 | | |
| Lincoln MO (D2) | 0 | @ | Arkansas-Pine Bluff | 42 | | |
| Louisiana Tech | 7 | @ | Army | 14 | | |
| NE10 | American Int'l (D2) | 43 | @ | Assumption (D2) | 24 | | |
| Wayne St NE (D2) | 28 | @ | Augustana SD (D2) | 7 | | |
| Rhodes (D3) | 14 | @ | Austin (D3) | 17 | | |
| OVC | Tennessee Tech | 28 | @ | Austin Peay | 31 | | |
| USASC | Greensboro (D3) | 14 | @ | Averett (D3) | 28 | | |
| Dixie St (D2) | 30 | @ | Azusa Pacific (NAIA) | 23 | | |
| OAC | Heidelberg (D3) | 37 | @ | Baldwin-Wallace (D3) | 34 | | |
| MAC | Eastern Michigan | 16 | @ | #17 Ball St | 38 | | |
| NESCAA | Colby (D3) | 21 | @ | Bates (D3) | 31 | | |
| Salisbury (D3) | 63 | @ | Becker (D3) | 0 | | |
| MSC | Cumberland TN (NAIA) | 46 | @ | Belhaven (NAIA) | 43 | | |
| Stillman (D2) | 36 | @ | Benedict (D2) | 21 | | |
| KCAC | Sterling (NAIA) | 47 | @ | Bethany KS (NAIA) | 0 | | |
| TPAC | Waynesburg (D3) | 24 | @ | Bethany WV (D3) | 31 | | |
| KCAC | Tabor (NAIA) | 7 | @ | Bethel KS (NAIA) | 54 | | |
| DAC | Minot St (NAIA) | 23 | @ | Black Hills St (NAIA) | 13 | | |
| CIAA | Virginia Union (D2) | 13 | @ | Bowie St (D2) | 14 | | |
| Carson-Newman (D2) | 34 | @ | Brevard (D2) | 3 | | |
| NEF | Westfield St (D3) | 21 | @ | Bridgewater St MA (D3) | 35 | | |
| ODC | Emory & Henry (D3) | 19 | @ | Bridgewater VA (D3) | 14 | | |
| MW | UNLV | 35 | @ | #24 Brigham Young | 42 | | |
| Western Conn St (D3) | 12 | @ | Brockport St (D3) | 13 | | |
| Ivy | Cornell NY | 7 | @ | Brown | 27 | | |
| Pat | Colgate | 52 | @ | Bucknell | 28 | | |
| Waldorf (NAIA) | 0 | @ | Buena Vista (D3) | 41 | | |
| Rowan (D3) | 20 | @ | Buffalo St (D3) | 7 | | |
| Pio | Morehead St | 21 | @ | Butler | 31 | | |
| East Stroudsburg (D2) | 48 | @ | C.W. Post (D2) | 42 | | |
| Chapman (D3) | 7 | @ | Cal Lutheran (D3) | 16 | | |
| GWest | Southern Utah | 41 | @ | Cal Poly SLO | 69 | | |
| P10 | UCLA | 20 | @ | California | 41 | | |
| PSAC | Slippery Rock (D2) | 10 | @ | California PA (D2) | 31 | | |
| OAC | Otterbein (D3) | 38 | @ | Capital (D3) | 9 | | |
| Wittenberg (D3) | 21 | @ | Carnegie Mellon (D3) | 14 | | |
| Front | Montana St-Northern (NAIA) | 0 | @ | Carroll MT (NAIA) | 37 | | |
| MidW | Knox (D3) | 0 | @ | Carroll WI (D3) | 14 | | |
| CCIW | Augustana IL (D3) | 40 | @ | Carthage (D3) | 16 | | |
| SLC | SE Louisiana St | 21 | @ | Central Arkansas | 28 | | |
| HAAC | Baker (NAIA) | 52 | @ | Central Methodist (NAIA) | 14 | | |
| Nebraska-Omaha (D2) | 38 | @ | Central Missouri (D2) | 33 | | |
| LSC | Midwestern St (D2) | 33 | @ | Central Oklahoma (D2) | 38 | | |
| GLFC | Missouri S&T (D2) | 28 | @ | Central St OH (D2) | 29 | | |
| Western Oregon (D2) | 31 | @ | Central Washington (D2) | 38 | | |
| SCAC | Birmingham-Southern (D3) | 6 | @ | Centre (D3) | 25 | | |
| RMAC | Colorado Mines (D2) | 17 | @ | Chadron St (D2) | 34 | | |
| Lake Erie (D2) | 34 | @ | Charleston WV (D2) | 55 | | |
| USASC | Methodist (D3) | 14 | @ | Christopher Newport (D3) | 38 | | |
| Worcester St (D3) | 14 | @ | Coast Guard (D3) | 17 | | |
| Stony Brook | 28 | @ | Coastal Carolina | 24 | | |
| Ivy | Dartmouth | 13 | @ | Columbia | 21 | | |
| Wisconsin Lutheran (D3) | 17 | @ | Concordia WI (D3) | 31 | | |
| Upper Iowa (D2) | 14 | @ | Concordia-St Paul (D2) | 23 | | |
| BigE | Cincinnati | 16 | @ | #23 Connecticut | 40 | | |
| IIAC | Central IA (D3) | 29 | @ | Cornell IA (D3) | 22 | | |
| NJAC | William Paterson (D3) | 0 | @ | Cortland St (D3) | 38 | | |
| DAC | Jamestown (NAIA) | 38 | @ | Dakota St (NAIA) | 21 | | |
| GPAC | Sioux Falls (NAIA) | 38 | @ | Dakota Wesleyan (NAIA) | 0 | | |
| GPAC | Hastings (NAIA) | 25 | @ | Dana (NAIA) | 21 | | |
| Pio | Valparaiso | 7 | @ | Dayton | 43 | | |
| HCA | Anderson (D3) | 13 | @ | Defiance (D3) | 21 | | |
| Chicago (D3) | 14 | @ | Denison (D3) | 26 | | |
| Colorado College (D3) | 34 | @ | DePauw (D3) | 37 | | |
| Cen | Gettysburg (D3) | 16 | @ | Dickinson (D3) | 29 | | |
| GPAC | Doane (NAIA) | 43 | @ | Dordt (NAIA) | 0 | | |
| Pio | Davidson | 17 | @ | Drake | 20 | | |
| NE | Sacred Heart | 29 | @ | Duquesne | 17 | | |
| LSC | SW Oklahoma St (D2) | 21 | @ | East Central OK (D2) | 42 | | |
| OVC | Eastern Illinois | 7 | @ | Eastern Kentucky | 20 | | |
| LSC | TAMU-Kingsville (D2) | 35 | @ | Eastern New Mexico (D2) | 32 | | |
| Montana-Western (NAIA) | 38 | @ | Eastern Oregon (NAIA) | 41 | | |
| CIAA | St Paul's (D2) | 9 | @ | Elizabeth City St (D2) | 39 | | |
| SoCon | Wofford | 55 | @ | Elon | 20 | | |
| MAIAA | Truman St (D2) | 24 | @ | Emporia St (D2) | 35 | | |
| IBC | MacMurray (D3) | 47 | @ | Eureka (D3) | 34 | | |
| HAAC | Culver-Stockton (NAIA) | 17 | @ | Evangel (NAIA) | 41 | | |
| WVIAC | WV Wesleyan (D2) | 0 | @ | Fairmont St (D2) | 31 | | |
| GLIAC | Northwood (D2) | 13 | @ | Ferris St (D2) | 19 | | |
| SEC | Kentucky | 5 | @ | #7 Florida | 63 | | |
| ACC | Virginia Tech | 20 | @ | #20 Florida St | 30 | | |
| Pat | Lafayette | 48 | @ | Fordham | 13 | | |
| Pittsburg St (D2) | 34 | @ | Fort Hays St (D2) | 7 | | |
| SIAC | Miles (D2) | 0 | @ | Fort Valley St (D2) | 24 | | |
| NEF | Maine Maritime (D3) | 51 | @ | Framingham St (D3) | 0 | | |
| KCAC | Southwestern KS (NAIA) | 0 | @ | Friends (NAIA) | 54 | | |
| BigS | VMI | 27 | @ | Gardner-Webb | 34 | | |
| MSC | Campbellsville (NAIA) | 45 | @ | Georgetown KY (NAIA) | 51 | | |
| ACC | #23 Virginia | 24 | @ | Georgia Tech | 17 | | |
| WVIAC | West Virginia St (D2) | 28 | @ | Glenville St (D2) | 50 | | |
| HAAC | Benedictine KS (NAIA) | 30 | @ | Graceland (NAIA) | 7 | | |
| GLIAC | Ashland (D2) | 42 | @ | Grand Valley St (D2) | 48 | | |
| Principia (D3) | 14 | @ | Greenville (D3) | 38 | | |
| MidW | Illinois College (D3) | 41 | @ | Grinnell (D3) | 14 | | |
| MIA | Augsburg (D3) | 31 | @ | Gustavus Adolphus (D3) | 34 | | |
| NESCAA | Williams (D3) | 14 | @ | Hamilton (D3) | 7 | | |
| MIA | Concordia-Moorhead (D3) | 18 | @ | Hamline (D3) | 17 | | |
| ODC | Catholic (D3) | 33 | @ | Hampden-Sydney (D3) | 21 | | |
| GSC | Arkansas-Monticello (D2) | 46 | @ | Harding (D2) | 43 | | |
| ASWC | Sul Ross St (D3) | 10 | @ | Hardin-Simmons (D3) | 55 | | |
| WAC | Nevada | 31 | @ | Hawaii | 38 | | |
| Case Western Reserve (D3) | 50 | @ | Hiram (D3) | 14 | | |
| CAAF | Delaware | 17 | @ | Hofstra | 0 | | |
| Pat | Lehigh | 21 | @ | Holy Cross | 35 | | |
| D3Ind | Gallaudet (D3) | 0 | @ | Husson (D3) | 49 | | |
| WAC | New Mexico St | 14 | @ | Idaho | 20 | | |
| North Dakota St | 25 | @ | Illinois St | 7 | | |
| CCIW | Elmhurst (D3) | 24 | @ | Illinois Wesleyan (D3) | 35 | | |
| B10 | Northwestern | 19 | @ | Indiana | 21 | | |
| PSAC | Clarion (D2) | 16 | @ | Indiana PA (D2) | 66 | | |
| MVC | South Dakota St | 49 | @ | Indiana St | 9 | | |
| B12 | Texas A&M | 49 | @ | Iowa St | 35 | | |
| E8 | Utica (D3) | 7 | @ | Ithaca (D3) | 42 | | |
| SWAC | Mississippi Valley St | 27 | @ | Jackson St | 29 | | |
| Pio | San Diego | 29 | @ | Jacksonville FL | 30 | | |
| OAC | Ohio Northern (D3) | 21 | @ | John Carroll (D3) | 14 | | |
| Chowan (D2) | 36 | @ | Johnson C. Smith (D2) | 51 | | |
| MidAC | Moravian (D3) | 23 | @ | Juniata (D3) | 17 | | |
| MIAA | Trine (D3) | 36 | @ | Kalamazoo (D3) | 35 | | |
| B12 | #8 Texas Tech | 63 | @ | Kansas | 21 | | |
| B12 | #5 Oklahoma | 58 | @ | Kansas St | 35 | | |
| NAIAInd | Faulkner (NAIA) | 23 | @ | Kentucky Christian (NAIA) | 21 | | |
| GLFC | St Joseph's IN (D2) | 36 | @ | Kentucky Wesleyan (D2) | 39 | | |
| MidAC | Lebanon Valley (D3) | 34 | @ | King's PA (D3) | 7 | | |
| PSAC | Millersville (D2) | 17 | @ | Kutztown (D2) | 26 | | |
| SCIAC | Occidental (D3) | 40 | @ | La Verne (D3) | 27 | | |
| IBC | Benedictine IL (D3) | 0 | @ | Lakeland (D3) | 26 | | |
| MSC | Bethel TN (NAIA) | 28 | @ | Lambuth (NAIA) | 48 | | |
| SIAC | Clark Atlanta (D2) | 12 | @ | Lane (D2) | 13 | | |
| NW Oklahoma St (NAIA) | 14 | @ | Langston (D2) | 28 | | |
| MidW | Beloit (D3) | 21 | @ | Lawrence (D3) | 6 | | |
| SAC | Mars Hill (D2) | 37 | @ | Lenoir-Rhyne (D2) | 24 | | |
| BigS | Charleston Southern | 0 | @ | Liberty | 42 | | |
| NWC | Willamette (D3) | 52 | @ | Linfield (D3) | 28 | | |
| CIAA | Shaw (D2) | 55 | @ | Livingstone (D2) | 7 | | |
| Gannon (D2) | 26 | @ | Lock Haven (D2) | 0 | | |
| IIAC | Dubuque (D3) | 0 | @ | Loras (D3) | 42 | | |
| ASWC | Howard Payne (D3) | 7 | @ | Louisiana College (D3) | 39 | | |
| SBC | Florida Atlantic | 29 | @ | Louisiana-Monroe | 28 | | |
| BigE | South Florida | 20 | @ | Louisville | 24 | | |
| SEC | #8 Georgia | 52 | @ | LSU | 38 | | |
| IIAC | Coe (D3) | 22 | @ | Luther (D3) | 19 | | |
| MidAC | Delaware Valley (D3) | 7 | @ | Lycoming (D3) | 10 | | |
| CAAF | Northeastern | 0 | @ | Maine | 20 | | |
| MSFA | Urbana (NAIA) | 6 | @ | Malone (NAIA) | 22 | | |
| HCA | Hanover (D3) | 35 | @ | Manchester (D3) | 34 | | |
| Concordia IL (D3) | 28 | @ | Maranatha Baptist (D3) | 21 | | |
| OAC | Muskingum (D3) | 22 | @ | Marietta (D3) | 30 | | |
| 1AAInd | Iona | 7 | @ | Marist | 28 | | |
| Macalester (D3) | 14 | @ | Martin Luther (NAIA) | 28 | | |
| St Cloud St (D2) | 14 | @ | Mary (D2) | 7 | | |
| ACC | North Carolina St | 24 | @ | Maryland | 27 | | |
| NEF | Fitchburg St (D3) | 42 | @ | Mass Maritime (D3) | 31 | | |
| Bryant (D2) | 7 | @ | Massachusetts | 42 | | |
| DAC | Valley City St (NAIA) | 45 | @ | Mayville St (NAIA) | 22 | | |
| MSFA | William Penn (NAIA) | 17 | @ | McKendree (NAIA) | 14 | | |
| ASWC | Texas Lutheran (D3) | 18 | @ | McMurry (D3) | 0 | | |
| SLC | Nicholls St | 38 | @ | McNeese St | 35 | | |
| KCAC | Ottawa (NAIA) | 45 | @ | McPherson (NAIA) | 35 | | |
| CUSA | Southern Miss | 30 | @ | Memphis | 36 | | |
| Whitworth (D3) | 36 | @ | Menlo (D3) | 34 | | |
| LL | Hobart (D3) | 24 | @ | Merchant Marine (D3) | 0 | | |
| ACC | Wake Forest | 10 | @ | Miami FL | 16 | | |
| MAC | Kent St | 54 | @ | Miami OH | 21 | | |
| B10 | #19 Michigan St | 35 | @ | Michigan | 21 | | |
| NSIC | Northern St SD (D2) | 26 | @ | Minn St-Moorhead (D3) | 29 | | |
| NSIC | Winona St (D2) | 50 | @ | Minnesota-Crookston (D2) | 26 | | |
| Bemidji St (D2) | 21 | @ | Minnesota-Duluth (D2) | 48 | | |
| ASWC | East Texas Baptist (D3) | 24 | @ | Mississippi College (D3) | 21 | | |
| Middle Tennessee St | 22 | @ | Mississippi St | 31 | | |
| B12 | Colorado | 0 | @ | #13 Missouri | 58 | | |
| MAIAA | Missouri Western (D2) | 17 | @ | Missouri Southern (D2) | 3 | | |
| MVC | Southern Illinois | 23 | @ | Missouri St | 17 | OT | |
| HAAC | Avila (NAIA) | 10 | @ | Missouri Valley (NAIA) | 41 | | |
| MidW | Lake Forest (D3) | 2 | @ | Monmouth IL (D3) | 56 | | |
| NE | Central Conn St | 20 | @ | Monmouth NJ | 30 | | |
| Front | Rocky Mountain (NAIA) | 17 | @ | Montana Tech (NAIA) | 24 | | |
| NJAC | New Jersey (D3) | 0 | @ | Montclair St (D3) | 15 | | |
| SIAC | Albany St GA (D2) | 19 | @ | Morehouse (D2) | 24 | | |
| MEAC | Delaware St | 3 | @ | Morgan St | 20 | | |
| GPAC | Midland Lutheran (NAIA) | 7 | @ | Morningside (NAIA) | 38 | | |
| Kean (D3) | 38 | @ | Morrisville St (D3) | 28 | | |
| Hartwick (D3) | 58 | @ | Mount Ida (D3) | 27 | | |
| HCA | Franklin (D3) | 40 | @ | Mt St Joseph (D3) | 35 | | |
| Cen | Franklin & Marshall (D3) | 6 | @ | Muhlenberg (D3) | 17 | | |
| SMU | 7 | @ | Navy | 34 | | |
| B12 | Baylor | 20 | @ | Nebraska | 32 | | |
| GPAC | Concordia NE (NAIA) | 0 | @ | Nebraska Wesleyan (NAIA) | 44 | | |
| RMAC | Fort Lewis (D2) | 0 | @ | Nebraska-Kearney (D2) | 24 | | |
| CAAF | Towson | 14 | @ | New Hampshire | 42 | | |
| RMAC | Western New Mexico (D2) | 14 | @ | New Mexico Highlands (D2) | 17 | | |
| NEF | UMass-Dartmouth (D3) | 33 | @ | Nichols (D3) | 22 | | |
| MEAC | Florida A&M | 31 | @ | Norfolk St | 28 | | |
| GSC | Valdosta St (D2) | 23 | @ | North Alabama (D2) | 41 | | |
| ACC | Boston College | 24 | @ | #17 North Carolina | 45 | | |
| MEAC | Howard | 20 | @ | North Carolina A&T | 21 | | |
| Edward Waters (NAIA) | 21 | @ | North Greenville (D2) | 45 | | |
| CCIW | Millikin (D3) | 35 | @ | North Park (D3) | 15 | | |
| SBC | Troy | 45 | @ | North Texas | 17 | | |
| BSky | Weber St | 42 | @ | Northern Arizona | 14 | | |
| BSky | Montana | 41 | @ | Northern Colorado | 20 | | |
| MAC | Bowling Green | 13 | @ | Northern Illinois | 16 | | |
| GLIAC | Findlay (D2) | 21 | @ | Northern Michigan (D2) | 29 | | |
| GPAC | Briar Cliff (NAIA) | 0 | @ | Northwestern IA (NAIA) | 35 | | |
| UMWAC | Minnesota-Morris (NAIA) | 14 | @ | Northwestern MN (NAIA) | 28 | | |
| SLC | Sam Houston St | 16 | @ | Northwestern St | 24 | | |
| NCA | Earlham (D3) | 56 | @ | Oberlin (D3) | 23 | | |
| MSFA | Taylor (NAIA) | 6 | @ | Ohio Dominican (NAIA) | 24 | | |
| B10 | #3 Penn State | 13 | @ | #11 Ohio State | 6 | | |
| Bacone (NAIA) | 34 | @ | OK Panhandle St (D2) | 28 | | |
| MIAA | Alma (D3) | 28 | @ | Olivet (D3) | 25 | | |
| MSFA | St Ambrose (NAIA) | 16 | @ | Olivet Nazarene (NAIA) | 10 | | |
| NE10 | Southern Conn St (D2) | 40 | @ | Pace (D2) | 17 | | |
| MSC | Virginia-Wise (NAIA) | 14 | @ | Pikeville (NAIA) | 6 | | |
| BigE | Rutgers | 54 | @ | Pittsburgh | 34 | | |
| Curry (D3) | 17 | @ | Plymouth St (D3) | 28 | | |
| SCIAC | Whittier (D3) | 35 | @ | Pomona-Pitzer (D3) | 42 | | |
| BSky | Idaho St | 13 | @ | Portland St | 36 | | |
| SWAC | Southern U. | 23 | vs | Prairie View A&M | 24 | | Houston TX |
| Ivy | Harvard | 24 | @ | Princeton | 20 | | |
| LaGrange (D3) | 59 | @ | Principia (D3) | 13 | | |
| NWC | Pacific Lutheran (D3) | 14 | @ | Puget Sound (D3) | 7 | | |
| B10 | #19 Minnesota | 17 | @ | Purdue | 6 | | |
| Frostburg St (D3) | 12 | @ | Randolph-Macon (D3) | 21 | | |
| SCIAC | Claremont-Mudd-Scripps (D3) | 0 | @ | Redlands (D3) | 48 | | |
| Georgetown DC | 0 | @ | Richmond | 48 | | |
| MidW | St Norbert (D3) | 7 | @ | Ripon (D3) | 19 | | |
| Aurora (D3) | 28 | @ | Rockford (D3) | 12 | | |
| Bluffton (D3) | 14 | @ | Rose-Hulman (D3) | 42 | | |
| BSky | Montana St | 31 | @ | Sacramento St | 20 | | |
| GLIAC | Michigan Tech (D2) | 23 | @ | Saginaw Valley St (D2) | 40 | | |
| NEF | MIT (D3) | 34 | @ | Salve Regina (D3) | 19 | | |
| The Citadel | 10 | @ | Samford | 28 | | |
| MW | Colorado St | 38 | @ | San Diego St | 34 | | |
| OVC | Tennessee St | 20 | @ | SE Missouri St | 27 | | |
| LSC | Northeastern St OK (D2) | 3 | @ | SE Oklahoma St (D2) | 28 | | |
| Concord (D2) | 0 | @ | Seton Hill (NAIA) | 31 | | |
| SCAC | Trinity TX (D3) | 27 | @ | Sewanee (D3) | 13 | | |
| USASC | North Carolina Wesleyan (D3) | 47 | @ | Shenandoah (D3) | 28 | | |
| PSAC | Bloomsburg (D2) | 21 | @ | Shippensburg (D2) | 0 | | |
| IIAC | Wartburg (D3) | 21 | @ | Simpson (D3) | 13 | | |
| MEAC | Hampton | 13 | @ | South Carolina St | 35 | | |
| DAC | Dickinson St (NAIA) | 24 | @ | South Dakota Tech (NAIA) | 19 | | |
| GSC | Delta St (D2) | 21 | @ | Southern Arkansas (D2) | 3 | | |
| CSFL | Texas College (NAIA) | 13 | @ | Southern Nazarene (NAIA) | 25 | | |
| Mary Hardin-Baylor (D3) | 28 | @ | Southern Oregon (NAIA) | 40 | | |
| NE10 | Bentley (D2) | 30 | @ | St Anselm (D2) | 12 | | |
| CIAA | Fayetteville St (D2) | 20 | @ | St Augustine's (D2) | 16 | | |
| MSFA | Quincy (NAIA) | 17 | @ | St Francis IL (NAIA) | 20 | | |
| MSFA | Walsh (NAIA) | 12 | @ | St Francis IN (NAIA) | 52 | | |
| E8 | Springfield (D3) | 35 | @ | St John Fisher (D3) | 38 | | |
| LL | RPI (D3) | 44 | @ | St Lawrence (D3) | 8 | | |
| KCAC | Kansas Wesleyan (NAIA) | 28 | @ | St Mary KS (NAIA) | 26 | | |
| MIA | St John's MN (D3) | 20 | @ | St Olaf (D3) | 14 | | |
| UMWAC | Trinity Bible (NAIA) | 8 | @ | St Scholastica (D3) | 47 | | |
| MIA | Carleton (D3) | 31 | @ | St Thomas (D3) | 33 | | |
| Geneva (NAIA) | 42 | @ | St Vincent (D3) | 19 | | |
| MSFA | Marian (NAIA) | 10 | @ | St Xavier (NAIA) | 53 | | |
| SLC | Texas St-San Marcos | 62 | @ | Stephen F. Austin | 21 | | |
| NE10 | Merrimack (D2) | 21 | @ | Stonehill (D2) | 16 | | |
| CSFL | Haskell (NAIA) | 14 | @ | SW Assem of God (NAIA) | 66 | | |
| Ouachita Baptist (D2) | 47 | @ | SW Baptist (D2) | 45 | | |
| Minn St-Mankato (D2) | 34 | @ | SW Minnesota St (D2) | 14 | | |
| MW | Wyoming | 7 | @ | #14 TCU | 54 | | |
| SEC | #3 Alabama | 29 | @ | Tennessee | 9 | | |
| B12 | #9 Oklahoma St | 24 | @ | #1 Texas | 28 | | |
| Thiel (D3) | 14 | @ | Thomas More (D3) | 45 | | |
| Indianapolis (D2) | 54 | @ | Tiffin (D2) | 12 | | |
| MAC | Central Michigan | 24 | @ | Toledo | 23 | | |
| NESCAA | Middlebury (D3) | 31 | @ | Trinity CT (D3) | 34 | | |
| MSFA | Iowa Wesleyan (NAIA) | 24 | @ | Trinity Int'l (NAIA) | 14 | | |
| CUSA | Rice | 42 | @ | Tulane | 17 | | |
| SAC | Newberry (D2) | 33 | @ | Tusculum (D2) | 45 | | |
| SIAC | Kentucky St (D2) | 34 | @ | Tuskegee (D2) | 52 | | |
| North Dakota (D2) | 21 | @ | UC-Davis | 34 | | |
| Cen | McDaniel (D3) | 7 | @ | Ursinus (D3) | 26 | | |
| WAC | Fresno St | 30 | @ | Utah St | 28 | | |
| WIAC | UW-La Crosse (D3) | 35 | @ | UW-Oshkosh (D3) | 7 | | |
| WIAC | UW-Eau Claire (D3) | 20 | @ | UW-Platteville (D3) | 10 | | |
| WIAC | UW-Stout (D3) | 29 | @ | UW-River Falls (D3) | 19 | | |
| WIAC | UW-Stevens Point (D3) | 17 | @ | UW-Whitewater (D3) | 16 | | |
| Duke | 10 | @ | Vanderbilt | 7 | | |
| CAAF | James Madison | 23 | @ | Villanova | 19 | | |
| CIAA | Lincoln PA (D2) | 0 | @ | Virginia St (D2) | 54 | | |
| NCA | Wooster (D3) | 24 | @ | Wabash (D3) | 45 | | |
| NE | Robert Morris | 35 | @ | Wagner | 3 | | |
| TPAC | Westminster PA (D3) | 7 | @ | Wash & Jeff (D3) | 34 | | |
| MAIAA | NW Missouri St (D2) | 24 | @ | Washburn (D2) | 21 | | |
| Notre Dame | 33 | @ | Washington | 7 | | |
| ODC | Guilford (D3) | 34 | @ | Washington and Lee (D3) | 27 | | |
| Ohio Wesleyan (D3) | 3 | @ | Washington U. (D3) | 24 | | |
| GLIAC | Hillsdale (D2) | 7 | @ | Wayne St MI (D2) | 14 | | |
| Wesley (D3) | 42 | @ | Webber Int'l (NAIA) | 13 | | |
| NESCAA | Bowdoin (D3) | 17 | @ | Wesleyan (D3) | 10 | | |
| GSC | West Georgia (D2) | 10 | @ | West Alabama (D2) | 48 | | |
| PSAC | Cheyney (D2) | 6 | @ | West Chester (D2) | 60 | | |
| WVIAC | Shepherd (D2) | 28 | @ | West Liberty St (D2) | 29 | | |
| Cumberlands KY (NAIA) | 28 | @ | West Virginia Tech (D2) | 19 | | |
| SoCon | Georgia Southern | 38 | @ | Western Carolina | 31 | OT | |
| NEF | Endicott (D3) | 20 | @ | Western New England (D3) | 27 | | |
| RMAC | Colorado St-Pueblo (D2) | 20 | @ | Western St CO (D2) | 17 | | |
| Humboldt St (D2) | 20 | @ | Western Washington (D2) | 56 | | |
| Huntingdon (D3) | 44 | @ | Westminster MO (D3) | 19 | | |
| CCIW | North Central (D3) | 44 | @ | Wheaton (D3) | 22 | | |
| CAAF | Rhode Island | 24 | @ | William & Mary | 34 | | |
| HAAC | Lindenwood (NAIA) | 20 | @ | William Jewell (NAIA) | 17 | | |
| OAC | Mount Union (D3) | 55 | @ | Wilmington (D3) | 0 | | |
| SAC | Catawba (D2) | 24 | @ | Wingate (D2) | 34 | | |
| MEAC | Bethune-Cookman | 27 | @ | Winston-Salem St | 6 | | |
| B10 | Illinois | 17 | @ | Wisconsin | 27 | | |
| LL | Rochester (D3) | 14 | @ | WPI (D3) | 21 | | |
| Ivy | Pennsylvania | 9 | @ | Yale | 7 | | |
| MVC | Northern Iowa | 21 | @ | Youngstown St | 20 | | |
| Sunday, 26 Oct 2008 |
| CUSA | Central Florida | 19 | @ | #19 Tulsa | 49 | | |
| Tuesday, 28 Oct 2008 |
| CUSA | Houston | 23 | @ | Marshall | 37 | | |
| MAC | Buffalo | 32 | @ | Ohio U. | 19 | | |