| 8/30/2008 | Prairie View | 34 | @ | Texas Southern | 14 | SWAC | |||
| 9/6/2008 | Texas College NAIA | 0 | @ | Prairie View | 53 | ||||
| 9/20/2008 | Prairie View | 49 | @ | MS Valley St | 15 | SWAC | |||
| 9/27/2008 | Morehouse D2 | 17 | @ | Prairie View | 21 | ||||
| 10/4/2008 | Prairie View | 16 | @ | Grambling | 40 | SWAC | |||
| 10/11/2008 | Alabama St | 6 | @ | Prairie View | 27 | SWAC | |||
| 10/18/2008 | Prairie View | 15 | @ | Ark Pine Bluff | 0 | SWAC | |||
| 10/25/2008 | Southern Univ | 23 | vs | Prairie View | 24 | SWAC | Houston TX | ||
| 11/8/2008 | Prairie View | 24 | @ | Alabama A&M | 10 | SWAC | |||
| 11/15/2008 | Alcorn St | 3 | @ | Prairie View | 37 | SWAC |