| 9/1/2022 | South Carolina State | 10 | at | UCF | 56 | MEAC (1AA) | ||
| 9/2/2022 | Temple | 0 | at | Duke | 30 | @ ACC | ||
| 9/3/2022 | Cincinnati | 24 | at | Arkansas | 31 | @ SEC | ||
| North Carolina State | 21 | at | East Carolina | 20 | ACC | |||
| Memphis | 23 | at | Mississippi State | 49 | @ SEC | |||
| Delaware | 14 | at | Navy | 7 | CAAF (1AA) | |||
| SMU | 48 | at | North Texas | 10 | @ CUSA | |||
| BYU | 50 | at | South Florida | 21 | Ind | |||
| Houston | 37 | at | Texas-San Antonio | 35 | 3OT | @ CUSA | ||
| Massachusetts | 10 | at | Tulane | 42 | Ind | |||
| Tulsa | 37 | at | Wyoming | 40 | 2OT | @ MW | ||
| 9/9/2022 | Louisville | 20 | at | UCF | 14 | ACC | ||
| 9/10/2022 | Kennesaw St | 10 | at | Cincinnati | 63 | ASUN (1AA) | ||
| Old Dominion | 21 | at | East Carolina | 39 | SBC | |||
| Memphis | 37 | at | Navy | 13 | ||||
| Lamar | 16 | at | SMU | 45 | SLC (1AA) | |||
| Howard | 20 | at | South Florida | 42 | MEAC (1AA) | |||
| Lafayette | 14 | at | Temple | 30 | Pat (1AA) | |||
| Houston | 30 | at | Texas Tech | 33 | 2OT | @ B12 | ||
| Alcorn State | 0 | at | Tulane | 52 | SWAC (1AA) | |||
| Northern Illinois | 35 | at | Tulsa | 38 | MAC | |||
| 9/17/2022 | Campbell | 10 | at | East Carolina | 49 | BigS (1AA) | ||
| South Florida | 28 | at | Florida | 31 | @ SEC | |||
| UCF | 40 | at | Florida Atlantic | 14 | @ CUSA | |||
| Kansas | 48 | at | Houston | 30 | B12 | |||
| Tulane | 17 | at | Kansas State | 10 | @ B12 | |||
| SMU | 27 | at | Maryland | 34 | @ B10 | |||
| Arkansas State | 32 | at | Memphis | 44 | SBC | |||
| Cincinnati | 38 | at | Miami-Ohio | 17 | @ MAC | |||
| Rutgers | 16 | at | Temple | 14 | B10 | |||
| Jacksonville State | 17 | at | Tulsa | 54 | ASUN (1AA) | |||
| 9/24/2022 | Georgia Tech | 10 | at | UCF | 27 | ACC | ||
| Indiana | 24 | at | Cincinnati | 45 | B10 | |||
| Navy | 23 | at | East Carolina | 20 | 2OT | |||
| Rice | 27 | at | Houston | 34 | CUSA | |||
| South Florida | 3 | at | Louisville | 41 | @ ACC | |||
| North Texas | 34 | at | Memphis | 44 | CUSA | |||
| Tulsa | 27 | at | Mississippi | 35 | @ SEC | |||
| TCU | 42 | at | SMU | 34 | B12 | |||
| Massachusetts | 0 | at | Temple | 28 | Ind | |||
| Southern Miss | 27 | at | Tulane | 24 | SBC | |||
| 9/30/2022 | Tulane | 27 | at | Houston | 24 | OT | ||
| 10/1/2022 | Navy | 10 | at | Air Force | 13 | @ MW | ||
| Temple | 3 | at | Memphis | 24 | ||||
| East Carolina | 48 | at | South Florida | 28 | ||||
| Cincinnati | 31 | at | Tulsa | 21 | ||||
| 10/5/2022 | SMU | 19 | at | UCF | 41 | |||
| 10/7/2022 | Houston | 33 | at | Memphis | 32 | |||
| 10/8/2022 | South Florida | 24 | at | Cincinnati | 28 | |||
| Tulsa | 21 | at | Navy | 53 | ||||
| East Carolina | 9 | at | Tulane | 24 | ||||
| 10/13/2022 | Temple | 13 | at | UCF | 70 | |||
| 10/14/2022 | Navy | 34 | at | SMU | 40 | |||
| 10/15/2022 | Memphis | 45 | at | East Carolina | 47 | 4OT | ||
| Tulane | 45 | at | South Florida | 31 | ||||
| 10/21/2022 | Tulsa | 27 | at | Temple | 16 | |||
| 10/22/2022 | UCF | 13 | at | East Carolina | 34 | |||
| Houston | 38 | at | Navy | 20 | ||||
| Cincinnati | 29 | at | SMU | 27 | ||||
| Memphis | 28 | at | Tulane | 38 | ||||
| 10/28/2022 | East Carolina | 27 | at | BYU | 24 | @ Ind | ||
| 10/29/2022 | Cincinnati | 21 | at | UCF | 25 | |||
| South Florida | 27 | at | Houston | 42 | ||||
| Temple | 20 | at | Navy | 27 | OT | |||
| SMU | 45 | at | Tulsa | 34 | ||||
| 11/5/2022 | Navy | 10 | at | Cincinnati | 20 | |||
| UCF | 35 | at | Memphis | 28 | ||||
| Houston | 63 | at | SMU | 77 | ||||
| South Florida | 28 | at | Temple | 54 | ||||
| Tulane | 27 | at | Tulsa | 13 | ||||
| 11/10/2022 | Tulsa | 10 | at | Memphis | 26 | |||
| 11/11/2022 | East Carolina | 25 | at | Cincinnati | 27 | |||
| 11/12/2022 | Temple | 36 | at | Houston | 43 | |||
| Notre Dame | 35 | vs | Navy | 32 | Baltimore MD | vs ND | ||
| SMU | 41 | at | South Florida | 23 | ||||
| UCF | 38 | at | Tulane | 31 | ||||
| 11/17/2022 | SMU | 24 | at | Tulane | 59 | |||
| 11/18/2022 | South Florida | 42 | at | Tulsa | 48 | |||
| 11/19/2022 | Navy | 17 | at | UCF | 14 | |||
| Houston | 42 | at | East Carolina | 3 | ||||
| North Alabama | 0 | at | Memphis | 59 | ASUN (1AA) | |||
| Cincinnati | 23 | at | Temple | 3 | ||||
| 11/25/2022 | Tulane | 27 | at | Cincinnati | 24 | |||
| 11/26/2022 | Tulsa | 37 | at | Houston | 30 | |||
| Memphis | 31 | at | SMU | 34 | ||||
| UCF | 46 | at | South Florida | 39 | ||||
| East Carolina | 49 | at | Temple | 46 | ||||
| 12/3/2022 | UCF | 28 | at | Tulane | 45 | AAC Championship | ||
| 12/10/2022 | Navy | 17 | vs | Army | 20 | 2OT | Philadelphia PA | vs Ind |
| 12/17/2022 | SMU | 23 | vs | BYU | 24 | Albuquerque NM | vs Ind | |
| Cincinnati | 7 | vs | Louisville | 24 | Boston MA | vs ACC | ||
| 12/23/2022 | UL Lafayette | 16 | vs | Houston | 23 | Shreveport LA | vs SBC | |
| 12/27/2022 | Coastal Carolina | 29 | vs | East Carolina | 53 | Birmingham AL | vs SBC | |
| Memphis | 38 | vs | Utah State | 10 | Dallas TX | vs MW | ||
| 12/28/2022 | UCF | 13 | vs | Duke | 30 | Annapolis MD | vs ACC | |
| 1/2/2023 | Tulane | 46 | vs | Southern California | 45 | Arlington TX | vs P12 |