| 8/27/2022 | Howard | 13 | vs | Alabama State (6-5) | 23 | Atlanta GA | vs SWAC | |
| 9/3/2022 | Howard | 28 | at | Hampton (4-7) | 31 | at CAAF | ||
| 9/10/2022 | Howard | 20 | at | South Florida (1-11) | 42 | at AAC | ||
| 9/17/2022 | Morehouse (1-9) | 0 | vs | Howard | 31 | East Rutherford NJ | SIAC (D2) | |
| 10/1/2022 | Howard | 26 | at | Yale (8-2) | 34 | at Ivy | ||
| 10/15/2022 | Harvard (6-4) | 41 | at | Howard | 25 | Ivy | ||
| 10/22/2022 | Delaware State (5-6,2-3) | 17 | at | Howard | 35 | |||
| 10/29/2022 | Howard | 49 | at | Norfolk State (2-9,2-3) | 21 | |||
| 11/5/2022 | Howard | 21 | at | North Carolina Central (10-2,4-1) | 50 | |||
| 11/12/2022 | South Carolina State (3-8,1-4) | 14 | at | Howard | 28 | |||
| 11/19/2022 | Howard | 35 | at | Morgan State (4-7,2-3) | 6 |
| vs Howard | vs Other Opponents | Howard compared to OOs | |
| Record: | 6-5 | 44-65 | |
| Points Scored: | 25.36 | 23.31 | -2.05 |
| Points Allowed: | 28.27 | 28.22 | 0.05 |
| Margin: | -2.91 | -4.91 | -2.00 |
| Total Points: | 53.63 | 51.53 | 2.10 |