| 9/3/2022 | South Dakota (3-8) | 0 | at | Kansas State | 34 | MVC (1AA) | ||
| 9/10/2022 | Missouri (6-7) | 12 | at | Kansas State | 40 | SEC | ||
| 9/17/2022 | Tulane (12-2) | 17 | at | Kansas State | 10 | AAC | ||
| 9/24/2022 | Kansas State | 41 | at | Oklahoma (6-7,3-6) | 34 | |||
| 10/1/2022 | Texas Tech (8-5,5-4) | 28 | at | Kansas State | 37 | |||
| 10/8/2022 | Kansas State | 10 | at | Iowa State (4-8,1-8) | 9 | |||
| 10/22/2022 | Kansas State | 28 | at | TCU (13-2,9-1) | 38 | |||
| 10/29/2022 | Oklahoma State (7-6,4-5) | 0 | at | Kansas State | 48 | |||
| 11/5/2022 | Texas (8-5,6-3) | 34 | at | Kansas State | 27 | |||
| 11/12/2022 | Kansas State | 31 | at | Baylor (6-7,4-5) | 3 | |||
| 11/19/2022 | Kansas State | 48 | at | West Virginia (5-7,3-6) | 31 | |||
| 11/26/2022 | Kansas (6-7,3-6) | 27 | at | Kansas State | 47 | |||
| 12/3/2022 | Kansas State | 31 | vs | TCU (13-2,9-1) | 28 | OT | B12 Arlington TX | |
| 12/31/2022 | Alabama (11-2) | 45 | vs | Kansas State | 20 | New Orleans LA | SEC |
| vs Kansas State | vs Other Opponents | Kansas State compared to OOs | |
| Record: | 4-10 | 103-64 | |
| Points Scored: | 21.86 | 33.57 | 11.71 |
| Points Allowed: | 32.29 | 26.87 | 5.42 |
| Margin: | -10.43 | 6.70 | 17.13 |
| Total Points: | 54.15 | 60.44 | -6.29 |