| 9/3/2022 | Massachusetts | 10 | at | Tulane (12-2) | 42 | at AAC | ||
| 9/10/2022 | Massachusetts | 10 | at | Toledo (9-5) | 55 | at MAC | ||
| 9/17/2022 | Stony Brook (2-9) | 3 | at | Massachusetts | 20 | CAAF (1AA) | ||
| 9/24/2022 | Massachusetts | 0 | at | Temple (3-9) | 28 | at AAC | ||
| 10/1/2022 | Massachusetts | 13 | at | Eastern Michigan (9-4) | 20 | at MAC | ||
| 10/8/2022 | Liberty (8-5,2-2) | 42 | at | Massachusetts | 24 | |||
| 10/15/2022 | Buffalo (7-6) | 34 | at | Massachusetts | 7 | MAC | ||
| 10/29/2022 | New Mexico State (7-6,2-0) | 23 | at | Massachusetts | 13 | |||
| 11/4/2022 | Massachusetts | 10 | at | Connecticut (6-7,2-1) | 27 | |||
| 11/12/2022 | Massachusetts | 33 | at | Arkansas State (3-9) | 35 | at SBC | ||
| 11/19/2022 | Massachusetts | 3 | at | Texas A&M (5-7) | 20 | at SEC | ||
| 11/26/2022 | Army (6-6,2-0) | 44 | at | Massachusetts | 7 |
| vs Massachusetts | vs Other Opponents | Massachusetts compared to OOs | |
| Record: | 11-1 | 66-74 | |
| Points Scored: | 31.08 | 25.81 | -5.27 |
| Points Allowed: | 12.50 | 27.20 | -14.70 |
| Margin: | 18.58 | -1.39 | -19.97 |
| Total Points: | 43.58 | 53.01 | -9.43 |