| 9/1/2022 | South Carolina State | 10 | at | UCF (9-5) | 56 | at AAC | ||
| 9/10/2022 | South Carolina State | 33 | at | Bethune-Cookman (2-9) | 9 | at SWAC | ||
| 9/24/2022 | South Carolina State | 27 | at | North Carolina A&T (7-4) | 41 | at BigS | ||
| 9/29/2022 | South Carolina State | 10 | at | South Carolina (8-5) | 50 | at SEC | ||
| 10/8/2022 | Florida A&M (9-2) | 20 | at | South Carolina State | 14 | SWAC | ||
| 10/15/2022 | Virginia U-Lynchburg (0-10) | 0 | at | South Carolina State | 36 | None (Unk?) | ||
| 10/22/2022 | North Carolina Central (10-2,4-1) | 24 | at | South Carolina State | 26 | |||
| 10/29/2022 | South Carolina State | 14 | at | Morgan State (4-7,2-3) | 41 | |||
| 11/5/2022 | Delaware State (5-6,2-3) | 27 | at | South Carolina State | 24 | OT | ||
| 11/12/2022 | South Carolina State | 14 | at | Howard (5-6,4-1) | 28 | |||
| 11/19/2022 | Norfolk State (2-9,2-3) | 42 | at | South Carolina State | 38 |
| vs South Carolina State | vs Other Opponents | South Carolina State compared to OOs | |
| Record: | 8-3 | 53-62 | |
| Points Scored: | 30.73 | 25.37 | -5.36 |
| Points Allowed: | 22.36 | 29.82 | -7.46 |
| Margin: | 8.37 | -4.45 | -12.82 |
| Total Points: | 53.09 | 55.19 | -2.10 |