| 9/1/2022 | Lamar | 14 | at | Abilene Christian (7-4) | 28 | at WAC | ||
| 9/10/2022 | Lamar | 16 | at | SMU (7-6) | 45 | at AAC | ||
| 9/17/2022 | Northern Colorado (3-8) | 21 | at | Lamar | 14 | BSky | ||
| 9/24/2022 | Lamar | 27 | at | Northwestern State (4-7,4-2) | 35 | |||
| 10/1/2022 | Houston Christian (2-9,1-5) | 37 | at | Lamar | 34 | |||
| 10/8/2022 | Lamar | 17 | at | Incarnate Word (12-2,6-1) | 56 | |||
| 10/22/2022 | Prairie View (6-5) | 54 | at | Lamar | 21 | SWAC | ||
| 10/29/2022 | Nicholls State (3-8,3-4) | 17 | at | Lamar | 24 | |||
| 11/5/2022 | Southeastern Louisiana (9-4,5-1) | 47 | at | Lamar | 31 | |||
| 11/12/2022 | Lamar | 14 | at | New Mexico State (7-6) | 51 | at Ind | ||
| 11/19/2022 | Lamar | 20 | at | McNeese State (4-7,2-4) | 24 |
| vs Lamar | vs Other Opponents | Lamar compared to OOs | |
| Record: | 10-1 | 54-65 | |
| Points Scored: | 37.73 | 28.02 | -9.71 |
| Points Allowed: | 21.09 | 31.12 | -10.03 |
| Margin: | 16.64 | -3.10 | -19.74 |
| Total Points: | 58.82 | 59.14 | -0.32 |