| 9/3/2022 | Sacred Heart (5-6) | 0 | at | Lafayette | 6 | NE | ||
| 9/10/2022 | Lafayette | 14 | at | Temple (3-9) | 30 | at AAC | ||
| 9/17/2022 | William & Mary (11-2) | 34 | at | Lafayette | 7 | CAAF | ||
| 9/24/2022 | Lafayette | 0 | at | Pennsylvania (8-2) | 12 | at Ivy | ||
| 10/1/2022 | Lafayette | 24 | at | Bucknell (3-8,2-4) | 14 | |||
| 10/8/2022 | Princeton (8-2) | 23 | at | Lafayette | 2 | Ivy | ||
| 10/22/2022 | Holy Cross (12-1,6-0) | 24 | at | Lafayette | 21 | |||
| 10/29/2022 | Georgetown (2-9,1-5) | 30 | at | Lafayette | 20 | |||
| 11/5/2022 | Lafayette | 21 | at | Colgate (3-8,2-4) | 16 | |||
| 11/12/2022 | Lafayette | 10 | at | Fordham (9-3,5-1) | 45 | |||
| 11/19/2022 | Lehigh (2-9,2-4) | 11 | at | Lafayette | 14 |
| vs Lafayette | vs Other Opponents | Lafayette compared to OOs | |
| Record: | 7-4 | 59-55 | |
| Points Scored: | 21.73 | 27.81 | 6.08 |
| Points Allowed: | 12.64 | 28.17 | -15.53 |
| Margin: | 9.09 | -0.36 | -9.45 |
| Total Points: | 34.37 | 55.98 | -21.61 |