| Thursday, 20 Nov 2008 | |||||||
| ACC | Miami FL | 23 | @ | #22 Georgia Tech | 41 | ||
| SWAC | Grambling St | 33 | @ | Texas Southern | 7 | ||
| Friday, 21 Nov 2008 | |||||||
| MAC | Buffalo | 40 | @ | Bowling Green | 34 | 2OT | |
| WAC | Fresno St | 24 | @ | San Jose St | 10 | ||
| MAC | Miami OH | 14 | @ | Toledo | 42 | ||
| Saturday, 22 Nov 2008 | |||||||
| LSC | West Texas A&M (D2) | 68 | @ | Abilene Christian (D2) | 93 | ||
| CUSA | East Carolina | 17 | @ | Alabama-Birmingham | 13 | ||
| SWAC | Jackson St | 26 | @ | Alcorn St | 21 | ||
| P10 | #17 Oregon St | 19 | @ | Arizona | 17 | ||
| SBC | Florida Atlantic | 14 | @ | Arkansas St | 28 | ||
| OVC | SE Missouri St | 33 | @ | Austin Peay | 30 | ||
| PSAC | West Chester (D2) | 21 | @ | Bloomsburg (D2) | 28 | ||
| Ivy | Columbia | 10 | @ | Brown | 41 | ||
| Pat | Fordham | 21 | @ | Bucknell | 24 | OT | |
| P10 | Stanford | 16 | @ | California | 37 | ||
| Seton Hill (NAIA) | 7 | @ | California PA (D2) | 48 | |||
| Dickinson St (NAIA) | 18 | @ | Carroll MT (NAIA) | 35 | |||
| Wabash (D3) | 20 | @ | Case Western Reserve (D3) | 17 | |||
| SLC | McNeese St | 30 | @ | Central Arkansas | 47 | ||
| Samford | 30 | @ | Chattanooga | 7 | |||
| BigE | Pittsburgh | 21 | @ | #16 Cincinnati | 28 | ||
| BigS | Charleston Southern | 24 | @ | Coastal Carolina | 0 | ||
| Pat | Holy Cross | 27 | @ | Colgate | 28 | ||
| Ivy | Pennsylvania | 23 | @ | Cornell NY | 6 | ||
| Plymouth St (D3) | 14 | @ | Cortland St (D3) | 31 | |||
| MSC | Shorter (NAIA) | 7 | @ | Cumberlands KY (NAIA) | 31 | ||
| Pio | Butler | 34 | @ | Davidson | 46 | ||
| CAAF | Villanova | 21 | @ | Delaware | 7 | ||
| Kean (D3) | 7 | @ | Delaware Valley (D3) | 16 | |||
| Tusculum (D2) | 19 | @ | Delta St (D2) | 27 | |||
| The Citadel | 19 | @ | #3 Florida | 70 | |||
| MEAC | Bethune-Cookman | 35 | vs | Florida A&M | 58 | Orlando FL | |
| SBC | Louisiana-Monroe | 31 | @ | Florida Int'l | 27 | ||
| NW Oklahoma St (NAIA) | 42 | @ | Friends (NAIA) | 7 | |||
| GLIAC | Ashland (D2) | 7 | @ | Grand Valley St (D2) | 40 | ||
| Brockport St (D3) | 70 | @ | Hartwick (D3) | 68 | |||
| Ivy | Yale | 0 | @ | Harvard | 10 | ||
| WAC | Idaho | 17 | @ | Hawaii | 49 | ||
| Lycoming (D3) | 15 | @ | Hobart (D3) | 33 | |||
| MIAA | Alma (D3) | 27 | @ | Hope (D3) | 45 | ||
| CUSA | UTEP | 37 | @ | Houston | 42 | ||
| MEAC | Delaware St | 10 | @ | Howard | 6 | ||
| St John Fisher (D3) | 17 | @ | Husson (D3) | 7 | |||
| BSky | Sacramento St | 33 | @ | Idaho St | 36 | OT | |
| MVC | Southern Illinois | 17 | @ | Illinois St | 10 | OT | |
| MVC | Missouri St | 27 | @ | Indiana St | 24 | OT | |
| Curry (D3) | 26 | @ | Ithaca (D3) | 21 | |||
| Pio | Dayton | 14 | @ | Jacksonville FL | 19 | ||
| Catholic (D3) | 18 | @ | Johns Hopkins (D3) | 17 | |||
| B12 | Iowa St | 30 | @ | Kansas St | 38 | ||
| Pat | Lehigh | 31 | @ | Lafayette | 15 | ||
| Elon | 3 | @ | Liberty | 26 | |||
| Lambuth (NAIA) | 48 | @ | Lindenwood (NAIA) | 65 | |||
| BigE | West Virginia | 35 | @ | Louisville | 21 | ||
| SEC | Mississippi | 31 | @ | LSU | 13 | ||
| CAAF | New Hampshire | 28 | @ | Maine | 24 | ||
| ASWC | Hardin-Simmons (D3) | 35 | @ | Mary Hardin-Baylor (D3) | 38 | ||
| ACC | #20 Florida St | 37 | @ | Maryland | 3 | ||
| CAAF | Hofstra | 14 | @ | Massachusetts | 28 | ||
| CUSA | Central Florida | 28 | @ | Memphis | 21 | ||
| Langston (D2) | 20 | @ | MidAmerica Nazarene (NAIA) | 14 | |||
| SBC | North Texas | 13 | @ | Middle Tennessee St | 52 | ||
| LaGrange (D3) | 26 | @ | Millsaps (D3) | 51 | |||
| B10 | Iowa | 55 | @ | Minnesota | 0 | ||
| Chadron St (D2) | 10 | @ | Minnesota-Duluth (D2) | 20 | |||
| SEC | Arkansas | 28 | @ | Mississippi St | 31 | ||
| SWAC | Alabama A&M | 58 | @ | Mississippi Valley St | 23 | ||
| Aurora (D3) | 13 | @ | Monmouth IL (D3) | 42 | |||
| BSky | Montana St | 3 | @ | Montana | 35 | ||
| Albright (D3) | 42 | @ | Montclair St (D3) | 14 | |||
| Salisbury (D3) | 21 | @ | Moravian (D3) | 17 | |||
| Pio | Campbell | 7 | @ | Morehead St | 42 | ||
| MEAC | Hampton | 17 | @ | Morgan St | 13 | ||
| Baker (NAIA) | 27 | @ | Morningside (NAIA) | 65 | |||
| Randolph-Macon (D3) | 0 | @ | Mount Union (D3) | 56 | |||
| Wesley (D3) | 20 | @ | Muhlenberg (D3) | 0 | |||
| OVC | Tennessee St | 17 | @ | Murray St | 24 | ||
| WAC | #10 Boise St | 41 | @ | Nevada | 34 | ||
| WAC | Louisiana Tech | 35 | @ | New Mexico St | 31 | ||
| SLC | SE Louisiana St | 28 | @ | Nicholls St | 35 | ||
| GSC | Valdosta St (D2) | 10 | @ | North Alabama (D2) | 37 | ||
| ACC | North Carolina St | 41 | @ | North Carolina | 10 | ||
| MEAC | South Carolina St | 55 | @ | North Carolina A&T | 0 | ||
| 1AAInd | Savannah St | 7 | @ | North Carolina Central | 10 | ||
| Thomas More (D3) | 23 | @ | North Central (D3) | 44 | |||
| South Dakota St | 25 | @ | North Dakota St | 24 | |||
| CAAF | Rhode Island | 29 | @ | Northeastern | 14 | ||
| B10 | Illinois | 10 | @ | Northwestern | 27 | ||
| Syracuse | 24 | @ | Notre Dame | 23 | |||
| MAIAA | Pittsburg St (D2) | 35 | @ | NW Missouri St (D2) | 38 | ||
| B10 | Michigan | 7 | @ | #10 Ohio State | 42 | ||
| MAC | Akron | 42 | @ | Ohio U. | 49 | ||
| B12 | #6 Texas Tech | 21 | @ | #3 Oklahoma | 65 | ||
| Franklin (D3) | 62 | @ | Otterbein (D3) | 45 | |||
| B10 | #19 Michigan St | 18 | @ | #7 Penn State | 49 | ||
| BSky | Northern Colorado | 21 | @ | Portland St | 24 | ||
| Ivy | Dartmouth | 10 | @ | Princeton | 28 | ||
| B10 | Indiana | 10 | @ | Purdue | 62 | ||
| CUSA | Marshall | 10 | @ | Rice | 35 | ||
| Alfred (D3) | 31 | @ | RPI (D3) | 34 | |||
| Army | 3 | @ | Rutgers | 30 | |||
| SLC | Texas St-San Marcos | 48 | @ | Sam Houston St | 45 | OT | |
| UC-Davis | 20 | @ | San Diego | 28 | |||
| MW | UNLV | 21 | @ | San Diego St | 42 | ||
| St Ambrose (NAIA) | 0 | @ | Sioux Falls (NAIA) | 28 | |||
| North Dakota (D2) | 34 | @ | South Dakota | 31 | OT | ||
| Northern Iowa | 34 | @ | Southern Utah | 24 | |||
| Union KY (NAIA) | 3 | @ | St Francis IN (NAIA) | 58 | |||
| Bryant (D2) | 23 | @ | St Francis PA | 0 | |||
| SLC | Northwestern St | 34 | @ | Stephen F. Austin | 24 | ||
| MW | Air Force | 10 | @ | #13 TCU | 44 | ||
| MAC | Eastern Michigan | 52 | @ | Temple | 55 | ||
| OVC | Eastern Illinois | 38 | @ | Tennessee Tech | 20 | ||
| OVC | Eastern Kentucky | 33 | @ | Tennessee-Martin | 31 | ||
| CAAF | James Madison | 58 | @ | Towson | 27 | ||
| Wheaton (D3) | 14 | @ | Trine (D3) | 0 | |||
| SBC | Louisiana-Lafayette | 3 | @ | Troy | 48 | ||
| CUSA | Tulane | 7 | @ | Tulsa | 56 | ||
| MW | #21 Brigham Young | 24 | @ | #6 Utah | 48 | ||
| Wartburg (D3) | 26 | @ | UW-Stevens Point (D3) | 21 | |||
| St John's MN (D3) | 7 | @ | UW-Whitewater (D3) | 37 | |||
| Pio | Drake | 32 | @ | Valparaiso | 0 | ||
| SEC | Tennessee | 20 | @ | Vanderbilt | 10 | ||
| ACC | Clemson | 13 | @ | Virginia | 3 | ||
| ACC | Duke | 3 | @ | Virginia Tech | 14 | ||
| Presbyterian | 27 | @ | VMI | 49 | |||
| ACC | #21 Boston College | 24 | @ | Wake Forest | 21 | ||
| Christopher Newport (D3) | 29 | @ | Wash & Jeff (D3) | 35 | |||
| P10 | Washington | 13 | @ | Washington St | 16 | 2OT | |
| BSky | Eastern Washington | 33 | @ | Weber St | 26 | ||
| SoCon | Appalachian St | 35 | @ | Western Carolina | 10 | ||
| MVC | Youngstown St | 31 | @ | Western Illinois | 28 | ||
| Occidental (D3) | 33 | @ | Willamette (D3) | 48 | |||
| CAAF | Richmond | 23 | @ | William & Mary | 20 | OT | |
| MEAC | Norfolk St | 17 | @ | Winston-Salem St | 14 | ||
| Cal Poly SLO | 35 | @ | Wisconsin | 36 | OT | ||
| SoCon | Furman | 10 | @ | Wofford | 35 | ||
| MW | Colorado St | 31 | @ | Wyoming | 20 | ||
| Sunday, 23 Nov 2008 | |||||||
| BigE | Connecticut | 13 | @ | South Florida | 17 | ||
| Tuesday, 25 Nov 2008 | |||||||
| MAC | Western Michigan | 22 | @ | #15 Ball St | 45 | ||
| Navy | 16 | @ | Northern Illinois | 0 | |||