| Thursday, 6 Nov 2008 |
| GSC | Ouachita Baptist (D2) | 43 | @ | Henderson St (D2) | 36 | | |
| MEAC | Howard | 0 | @ | South Carolina St | 56 | | |
| MW | #15 TCU | 10 | @ | #7 Utah | 13 | | |
| ACC | Maryland | 13 | @ | Virginia Tech | 23 | | |
| Friday, 7 Nov 2008 |
| WAC | Nevada | 41 | @ | Fresno St | 28 | | |
| Front | Montana Tech (NAIA) | 3 | @ | Montana St-Northern (NAIA) | 35 | | |
| Ivy | Pennsylvania | 14 | @ | Princeton | 9 | | |
| Saturday, 8 Nov 2008 |
| LSC | Midwestern St (D2) | 17 | @ | Abilene Christian (D2) | 47 | | |
| MIAA | Trine (D3) | 9 | @ | Adrian (D3) | 0 | | |
| MW | Colorado St | 17 | @ | Air Force | 38 | | |
| SWAC | Prairie View A&M | 24 | @ | Alabama A&M | 10 | | |
| SWAC | Jackson St | 20 | @ | Alabama St | 0 | | |
| SIAC | Miles (D2) | 0 | @ | Albany St GA (D2) | 42 | | |
| MIAA | Kalamazoo (D3) | 20 | @ | Albion (D3) | 23 | | |
| MidAC | Widener (D3) | 10 | @ | Albright (D3) | 21 | | |
| E8 | Ithaca (D3) | 43 | @ | Alfred (D3) | 35 | | |
| NCA | Wittenberg (D3) | 27 | @ | Allegheny (D3) | 30 | | |
| NE10 | Southern Conn St (D2) | 27 | @ | American Int'l (D2) | 17 | | |
| NESCAA | Williams (D3) | 24 | @ | Amherst (D3) | 23 | | |
| LSC | TAMU-Kingsville (D2) | 38 | @ | Angelo St (D2) | 14 | | |
| GSC | Harding (D2) | 34 | @ | Arkansas Tech (D2) | 56 | | |
| GSC | Southern Arkansas (D2) | 23 | @ | Arkansas-Monticello (D2) | 16 | | |
| SWAC | Grambling St | 28 | vs | Arkansas-Pine Bluff | 7 | | Little Rock AR |
| GLIAC | Findlay (D2) | 38 | @ | Ashland (D2) | 45 | | |
| NE10 | Merrimack (D2) | 34 | @ | Assumption (D2) | 7 | | |
| Tennessee-Martin | 20 | @ | Auburn | 37 | | |
| Haskell (NAIA) | 7 | @ | Avila (NAIA) | 24 | | |
| East Texas Baptist (D3) | 21 | @ | Azusa Pacific (NAIA) | 33 | | |
| CSFL | NW Oklahoma St (NAIA) | 52 | @ | Bacone (NAIA) | 7 | | |
| NESCAA | Hamilton (D3) | 22 | @ | Bates (D3) | 23 | | |
| Husson (D3) | 48 | @ | Becker (D3) | 13 | | |
| NSIC | Concordia-St Paul (D2) | 12 | @ | Bemidji St (D2) | 24 | | |
| SIAC | Clark Atlanta (D2) | 14 | @ | Benedict (D2) | 3 | | |
| KCAC | Friends (NAIA) | 41 | @ | Bethel KS (NAIA) | 7 | | |
| SCAC | Sewanee (D3) | 0 | @ | Birmingham-Southern (D3) | 49 | | |
| UMWAC | Westminster MO (D3) | 37 | @ | Blackburn (D3) | 6 | | |
| HCA | Hanover (D3) | 42 | @ | Bluffton (D3) | 19 | | |
| WAC | Utah St | 14 | @ | #9 Boise St | 49 | | |
| Notre Dame | 0 | @ | Boston College | 17 | | |
| Newberry (D2) | 17 | @ | Brevard (D2) | 0 | | |
| NEF | Mass Maritime (D3) | 7 | @ | Bridgewater St MA (D3) | 34 | | |
| MW | San Diego St | 12 | @ | #23 Brigham Young | 41 | | |
| Ivy | Yale | 13 | @ | Brown | 3 | | |
| Pat | Lafayette | 38 | @ | Bucknell | 21 | | |
| IIAC | Central IA (D3) | 23 | @ | Buena Vista (D3) | 14 | | |
| Morrisville St (D3) | 20 | @ | Buffalo St (D3) | 52 | | |
| Pio | Dayton | 28 | @ | Butler | 21 | OT | |
| SCIAC | La Verne (D3) | 3 | @ | Cal Lutheran (D3) | 37 | | |
| North Carolina Central | 3 | @ | Cal Poly SLO | 49 | | |
| PSAC | Shippensburg (D2) | 36 | @ | California PA (D2) | 47 | | |
| Eastern Oregon (NAIA) | 7 | @ | Carroll MT (NAIA) | 28 | | |
| UAA | Carnegie Mellon (D3) | 13 | @ | Case Western Reserve (D3) | 38 | | |
| SLC | Northwestern St | 6 | @ | Central Arkansas | 42 | | |
| NE | St Francis PA | 0 | @ | Central Conn St | 36 | | |
| CUSA | Southern Miss | 17 | @ | Central Florida | 6 | | |
| HAAC | Lindenwood (NAIA) | 35 | @ | Central Methodist (NAIA) | 7 | | |
| NCC | Western Washington (D2) | 21 | @ | Central Washington (D2) | 49 | | |
| SCAC | Trinity TX (D3) | 17 | @ | Centre (D3) | 26 | | |
| RMAC | Western St CO (D2) | 7 | @ | Chadron St (D2) | 39 | | |
| Presbyterian | 18 | @ | Charleston Southern | 29 | | |
| SoCon | Appalachian St | 49 | @ | Chattanooga | 7 | | |
| UAA | Washington U. (D3) | 14 | @ | Chicago (D3) | 17 | | |
| USASC | Averett (D3) | 13 | @ | Christopher Newport (D3) | 19 | | |
| SCIAC | Whittier (D3) | 6 | @ | Claremont-Mudd-Scripps (D3) | 31 | | |
| PSAC | Cheyney (D2) | 20 | @ | Clarion (D2) | 41 | | |
| Framingham St (D3) | 25 | @ | Coast Guard (D3) | 23 | | |
| NESCAA | Bowdoin (D3) | 20 | @ | Colby (D3) | 6 | | |
| B12 | Iowa St | 24 | @ | Colorado | 28 | | |
| RMAC | Adams St (D2) | 16 | @ | Colorado St-Pueblo (D2) | 8 | | |
| WVIAC | Fairmont St (D2) | 27 | @ | Concord (D2) | 8 | | |
| IBC | Aurora (D3) | 63 | @ | Concordia IL (D3) | 6 | | |
| MIA | Carleton (D3) | 41 | @ | Concordia-Moorhead (D3) | 28 | | |
| Ivy | Dartmouth | 14 | @ | Cornell NY | 37 | | |
| Brockport St (D3) | 30 | @ | Cortland St (D3) | 42 | | |
| Kentucky Christian (NAIA) | 14 | @ | Cumberland TN (NAIA) | 51 | | |
| MSC | Virginia-Wise (NAIA) | 37 | @ | Cumberlands KY (NAIA) | 56 | | |
| GPAC | Midland Lutheran (NAIA) | 21 | @ | Dana (NAIA) | 0 | | |
| Pio | San Diego | 28 | @ | Davidson | 24 | | |
| HCA | Mt St Joseph (D3) | 14 | @ | Defiance (D3) | 21 | | |
| CAAF | Towson | 21 | @ | Delaware | 31 | | |
| MEAC | Winston-Salem St | 27 | @ | Delaware St | 26 | | |
| NCA | Kenyon (D3) | 7 | @ | Denison (D3) | 21 | | |
| SCAC | Rhodes (D3) | 12 | @ | DePauw (D3) | 28 | | |
| GPAC | Sioux Falls (NAIA) | 34 | @ | Dordt (NAIA) | 2 | | |
| Pio | Morehead St | 15 | @ | Drake | 19 | | |
| ACC | North Carolina St | 27 | @ | Duke | 17 | | |
| NCA | Ohio Wesleyan (D3) | 7 | @ | Earlham (D3) | 14 | | |
| CUSA | Marshall | 16 | @ | East Carolina | 19 | OT | |
| PSAC | Millersville (D2) | 13 | @ | Edinboro (D2) | 38 | | |
| Savannah St | 21 | @ | Edward Waters (NAIA) | 26 | | |
| SoCon | Western Carolina | 14 | @ | Elon | 33 | | |
| MAIAA | Pittsburg St (D2) | 52 | @ | Emporia St (D2) | 7 | | |
| IBC | Greenville (D3) | 49 | @ | Eureka (D3) | 26 | | |
| HAAC | Benedictine KS (NAIA) | 14 | @ | Evangel (NAIA) | 13 | | |
| Bethel TN (NAIA) | 38 | vs | Faulkner (NAIA) | 6 | | Prattville AL |
| GLIAC | Saginaw Valley St (D2) | 26 | @ | Ferris St (D2) | 14 | | |
| USASC | North Carolina Wesleyan (D3) | 41 | @ | Ferrum (D3) | 14 | | |
| SBC | North Texas | 13 | @ | Florida Atlantic | 46 | | |
| SBC | Arkansas St | 21 | @ | Florida Int'l | 22 | | |
| ACC | Clemson | 27 | @ | #21 Florida St | 41 | | |
| Central Missouri (D2) | 24 | @ | Fort Hays St (D2) | 21 | | |
| Cen | Johns Hopkins (D3) | 26 | @ | Franklin & Marshall (D3) | 25 | | |
| ACF | Apprentice (D3) | 7 | @ | Frostburg St (D3) | 20 | | |
| Bloomsburg (D2) | 38 | @ | Gannon (D2) | 10 | | |
| BigS | Coastal Carolina | 23 | @ | Gardner-Webb | 18 | | |
| Thomas More (D3) | 13 | @ | Geneva (NAIA) | 17 | | |
| Marist | 12 | @ | Georgetown DC | 13 | | |
| Samford | 27 | @ | Georgia Southern | 17 | | |
| WVIAC | Charleston WV (D2) | 20 | @ | Glenville St (D2) | 50 | | |
| MidW | Beloit (D3) | 34 | @ | Grinnell (D3) | 12 | | |
| ODC | Catholic (D3) | 49 | @ | Guilford (D3) | 34 | | |
| Macalester (D3) | 7 | @ | Hamline (D3) | 52 | | |
| MEAC | Bethune-Cookman | 17 | @ | Hampton | 6 | | |
| ASWC | McMurry (D3) | 20 | @ | Hardin-Simmons (D3) | 45 | | |
| Ivy | Columbia | 28 | @ | Harvard | 42 | | |
| GPAC | Concordia NE (NAIA) | 7 | @ | Hastings (NAIA) | 36 | | |
| NCA | Wabash (D3) | 63 | @ | Hiram (D3) | 0 | | |
| CAAF | Richmond | 34 | @ | Hofstra | 14 | | |
| Pat | Fordham | 17 | @ | Holy Cross | 38 | | |
| CUSA | Tulane | 14 | @ | Houston | 42 | | |
| D2Ind | Dixie St (D2) | 19 | @ | Humboldt St (D2) | 15 | | |
| Hampden-Sydney (D3) | 38 | @ | Huntingdon (D3) | 34 | | |
| BSky | Weber St | 59 | @ | Idaho St | 27 | | |
| B10 | Wisconsin | 55 | @ | Indiana | 20 | | |
| PSAC | Kutztown (D2) | 7 | @ | Indiana PA (D2) | 34 | | |
| GLIAC | Northern Michigan (D2) | 6 | @ | Indianapolis (D2) | 24 | | |
| 1AAInd | Stony Brook | 68 | @ | Iona | 9 | | |
| B10 | #8 Penn State | 23 | @ | Iowa | 24 | | |
| MSFA | William Penn (NAIA) | 35 | @ | Iowa Wesleyan (NAIA) | 13 | | |
| DAC | Valley City St (NAIA) | 31 | @ | Jamestown (NAIA) | 35 | | |
| Dickinson (D3) | 53 | @ | Juniata (D3) | 41 | | |
| KCAC | Bethany KS (NAIA) | 7 | @ | Kansas Wesleyan (NAIA) | 38 | | |
| NJAC | William Paterson (D3) | 21 | @ | Kean (D3) | 28 | | |
| SEC | #10 Georgia | 42 | @ | Kentucky | 38 | | |
| GLFC | Lincoln MO (D2) | 14 | @ | Kentucky Wesleyan (D2) | 36 | | |
| MidAC | Lycoming (D3) | 7 | @ | King's PA (D3) | 24 | | |
| Wesley (D3) | 47 | @ | Lake Erie (D2) | 26 | | |
| MidW | Carroll WI (D3) | 27 | @ | Lake Forest (D3) | 12 | | |
| IBC | Concordia WI (D3) | 7 | @ | Lakeland (D3) | 37 | | |
| MSC | Georgetown KY (NAIA) | 7 | @ | Lambuth (NAIA) | 42 | | |
| MidW | Ripon (D3) | 42 | @ | Lawrence (D3) | 14 | | |
| MidAC | FDU-Florham (D3) | 3 | @ | Lebanon Valley (D3) | 38 | | |
| Pat | Colgate | 34 | @ | Lehigh | 33 | | |
| SAC | Catawba (D2) | 58 | @ | Lenoir-Rhyne (D2) | 23 | | |
| Western Oregon (D2) | 17 | @ | Linfield (D3) | 9 | | |
| C.W. Post (D2) | 30 | @ | Lock Haven (D2) | 28 | | |
| ASWC | Texas Lutheran (D3) | 7 | @ | Louisiana College (D3) | 29 | | |
| UTEP | 37 | @ | Louisiana-Lafayette | 24 | | |
| SEC | #4 Alabama | 27 | @ | LSU | 21 | OT | |
| IIAC | Cornell IA (D3) | 0 | @ | Luther (D3) | 7 | | |
| NEF | Fitchburg St (D3) | 32 | @ | Maine Maritime (D3) | 66 | | |
| HCA | Franklin (D3) | 31 | @ | Manchester (D3) | 20 | | |
| MSFA | Walsh (NAIA) | 31 | @ | Marian (NAIA) | 34 | | |
| OAC | Heidelberg (D3) | 42 | @ | Marietta (D3) | 40 | | |
| NSIC | Wayne St NE (D2) | 31 | @ | Mary (D2) | 16 | | |
| ASWC | Howard Payne (D3) | 0 | @ | Mary Hardin-Baylor (D3) | 67 | | |
| Shenandoah (D3) | 20 | @ | Maryville (D3) | 23 | | |
| CAAF | Maine | 21 | @ | Massachusetts | 20 | | |
| DAC | Dakota St (NAIA) | 32 | @ | Mayville St (NAIA) | 13 | | |
| Cen | Gettysburg (D3) | 38 | @ | McDaniel (D3) | 9 | | |
| MSFA | Olivet Nazarene (NAIA) | 0 | @ | McKendree (NAIA) | 38 | | |
| SLC | Stephen F. Austin | 31 | @ | McNeese St | 42 | | |
| Pacific Lutheran (D3) | 35 | @ | Menlo (D3) | 34 | | |
| West Chester (D2) | 17 | @ | Mercyhurst (D2) | 21 | | |
| USASC | Greensboro (D3) | 10 | @ | Methodist (D3) | 20 | | |
| B10 | Purdue | 7 | @ | #17 Michigan St | 21 | | |
| HAAC | Baker (NAIA) | 41 | @ | MidAmerica Nazarene (NAIA) | 42 | | |
| SBC | Louisiana-Monroe | 21 | @ | Middle Tennessee St | 24 | | |
| NESCAA | Tufts (D3) | 24 | @ | Middlebury (D3) | 38 | | |
| CCIW | Elmhurst (D3) | 24 | @ | Millikin (D3) | 21 | | |
| Colorado College (D3) | 6 | @ | Millsaps (D3) | 50 | | |
| NCC | St Cloud St (D2) | 7 | @ | Minn St-Mankato (D2) | 16 | | |
| NSIC | SW Minnesota St (D2) | 22 | @ | Minn St-Moorhead (D3) | 8 | | |
| B10 | Michigan | 29 | @ | Minnesota | 6 | | |
| Winona St (D2) | 7 | @ | Minnesota-Duluth (D2) | 38 | | |
| DAC | Dickinson St (NAIA) | 28 | @ | Minot St (NAIA) | 21 | | |
| ASWC | Sul Ross St (D3) | 10 | @ | Mississippi College (D3) | 41 | | |
| B12 | Kansas St | 24 | @ | #12 Missouri | 41 | | |
| SW Baptist (D2) | 23 | @ | Missouri S&T (D2) | 63 | | |
| MAIAA | NW Missouri St (D2) | 48 | @ | Missouri Southern (D2) | 24 | | |
| HAAC | Culver-Stockton (NAIA) | 7 | @ | Missouri Valley (NAIA) | 59 | | |
| MAIAA | Truman St (D2) | 32 | @ | Missouri Western (D2) | 33 | | |
| NEF | Endicott (D3) | 39 | @ | MIT (D3) | 18 | | |
| MidW | Knox (D3) | 10 | @ | Monmouth IL (D3) | 56 | | |
| NE | Sacred Heart | 7 | @ | Monmouth NJ | 19 | | |
| Front | Rocky Mountain (NAIA) | 31 | @ | Montana-Western (NAIA) | 26 | | |
| NJAC | Rowan (D3) | 14 | @ | Montclair St (D3) | 30 | | |
| SIAC | Kentucky St (D2) | 55 | @ | Morehouse (D2) | 58 | | |
| GPAC | Briar Cliff (NAIA) | 8 | @ | Morningside (NAIA) | 73 | | |
| D3Ind | SUNY-Maritime (D3) | 28 | @ | Mount Ida (D3) | 35 | | |
| Cen | Ursinus (D3) | 8 | @ | Muhlenberg (D3) | 45 | | |
| OVC | SE Missouri St | 10 | @ | Murray St | 17 | | |
| OAC | John Carroll (D3) | 14 | @ | Muskingum (D3) | 15 | | |
| B12 | Kansas | 35 | @ | Nebraska | 45 | | |
| GPAC | Doane (NAIA) | 0 | @ | Nebraska Wesleyan (NAIA) | 23 | | |
| RMAC | Mesa St (D2) | 10 | @ | Nebraska-Kearney (D2) | 63 | | |
| RMAC | Colorado Mines (D2) | 20 | @ | New Mexico Highlands (D2) | 7 | | |
| WAC | Hawaii | 42 | @ | New Mexico St | 30 | | |
| SLC | Sam Houston St | 47 | @ | Nicholls St | 37 | | |
| NEF | Western New England (D3) | 42 | @ | Nichols (D3) | 14 | | |
| MEAC | Morgan St | 9 | @ | Norfolk St | 35 | | |
| ACC | Georgia Tech | 7 | @ | #15 North Carolina | 28 | | |
| MEAC | Florida A&M | 45 | @ | North Carolina A&T | 7 | | |
| CCIW | Augustana IL (D3) | 28 | @ | North Central (D3) | 41 | | |
| Southern Utah | 15 | @ | North Dakota (D2) | 14 | | |
| CCIW | Carthage (D3) | 48 | @ | North Park (D3) | 19 | | |
| LSC | Central Oklahoma (D2) | 24 | @ | Northeastern St OK (D2) | 13 | | |
| BSky | Montana St | 25 | @ | Northern Arizona | 23 | | |
| BSky | Eastern Washington | 31 | @ | Northern Colorado | 16 | | |
| MVC | Missouri St | 0 | @ | Northern Iowa | 42 | | |
| Augustana SD (D2) | 43 | @ | Northern St SD (D2) | 7 | | |
| B10 | #11 Ohio State | 45 | @ | Northwestern | 10 | | |
| GPAC | Dakota Wesleyan (NAIA) | 17 | @ | Northwestern IA (NAIA) | 6 | | |
| GLIAC | Michigan Tech (D2) | 25 | @ | Northwood (D2) | 13 | | |
| NCA | Wooster (D3) | 27 | @ | Oberlin (D3) | 7 | | |
| SCIAC | Pomona-Pitzer (D3) | 33 | @ | Occidental (D3) | 64 | | |
| MSFA | Urbana (NAIA) | 0 | @ | Ohio Dominican (NAIA) | 56 | | |
| OAC | Capital (D3) | 21 | @ | Ohio Northern (D3) | 36 | | |
| MAC | Bowling Green | 28 | @ | Ohio U. | 3 | | |
| Eastern New Mexico (D2) | 59 | @ | OK Panhandle St (D2) | 13 | | |
| P10 | Stanford | 28 | @ | Oregon | 35 | | |
| KCAC | Southwestern KS (NAIA) | 3 | @ | Ottawa (NAIA) | 73 | | |
| OAC | Mount Union (D3) | 49 | @ | Otterbein (D3) | 20 | | |
| NE10 | St Anselm (D2) | 28 | @ | Pace (D2) | 14 | | |
| Grand View (NAIA) | 17 | @ | Peru St (NAIA) | 18 | | |
| BigE | Louisville | 7 | @ | #22 Pittsburgh | 41 | | |
| Salve Regina (D3) | 7 | @ | Plymouth St (D3) | 34 | | |
| BSky | Montana | 29 | @ | Portland St | 12 | | |
| MacMurray (D3) | 13 | @ | Principia (D3) | 6 | | |
| MSFA | St Ambrose (NAIA) | 34 | @ | Quincy (NAIA) | 27 | | |
| ODC | Bridgewater VA (D3) | 18 | @ | Randolph-Macon (D3) | 40 | | |
| Chapman (D3) | 7 | @ | Redlands (D3) | 21 | | |
| Army | 31 | @ | Rice | 38 | | |
| NE | Albany | 41 | @ | Robert Morris | 7 | | |
| LL | St Lawrence (D3) | 20 | @ | Rochester (D3) | 34 | | |
| UMWAC | Maranatha Baptist (D3) | 0 | @ | Rockford (D3) | 20 | | |
| Anderson (D3) | 35 | @ | Rose-Hulman (D3) | 31 | | |
| LL | Hobart (D3) | 20 | @ | RPI (D3) | 17 | | |
| BigE | Syracuse | 17 | @ | Rutgers | 35 | | |
| WAC | Louisiana Tech | 21 | @ | San Jose St | 0 | | |
| SLC | Texas St-San Marcos | 38 | @ | SE Louisiana St | 24 | | |
| LSC | East Central OK (D2) | 31 | @ | SE Oklahoma St (D2) | 38 | | |
| West Liberty St (D2) | 35 | @ | Seton Hill (NAIA) | 32 | | |
| CIAA | Elizabeth City St (D2) | 7 | vs | Shaw (D2) | 36 | | Durham NC |
| MSC | Belhaven (NAIA) | 0 | @ | Shorter (NAIA) | 35 | | |
| IIAC | Loras (D3) | 6 | @ | Simpson (D3) | 21 | | |
| PSAC | East Stroudsburg (D2) | 38 | @ | Slippery Rock (D2) | 21 | | |
| CUSA | Memphis | 31 | @ | SMU | 26 | | |
| SEC | Arkansas | 21 | @ | South Carolina | 34 | | |
| Southern Oregon (NAIA) | 0 | @ | South Dakota | 37 | | |
| MVC | Illinois St | 21 | @ | South Dakota St | 52 | | |
| P10 | California | 3 | @ | #6 Southern Cal | 17 | | |
| MVC | Western Illinois | 14 | @ | Southern Illinois | 24 | | |
| Langston (D2) | 30 | @ | Southern Nazarene (NAIA) | 7 | | |
| NAIAInd | Webber Int'l (NAIA) | 23 | @ | Southern Virginia (NAIA) | 15 | | |
| E8 | Hartwick (D3) | 31 | @ | Springfield (D3) | 45 | | |
| MSFA | Malone (NAIA) | 24 | @ | St Francis IN (NAIA) | 45 | | |
| MIA | Augsburg (D3) | 21 | @ | St John's MN (D3) | 28 | | |
| GLFC | Central St OH (D2) | 7 | @ | St Joseph's IN (D2) | 30 | | |
| MidW | Illinois College (D3) | 27 | @ | St Norbert (D3) | 42 | | |
| MIA | Gustavus Adolphus (D3) | 20 | @ | St Olaf (D3) | 27 | | |
| UMWAC | Martin Luther (NAIA) | 49 | @ | St Scholastica (D3) | 20 | | |
| MIA | Bethel MN (D3) | 20 | @ | St Thomas (D3) | 36 | | |
| MSFA | Taylor (NAIA) | 15 | @ | St Xavier (NAIA) | 29 | | |
| KCAC | St Mary KS (NAIA) | 48 | @ | Sterling (NAIA) | 7 | | |
| Fort Valley St (D2) | 15 | @ | Stillman (D2) | 6 | | |
| NE10 | Bentley (D2) | 7 | @ | Stonehill (D2) | 35 | | |
| KCAC | McPherson (NAIA) | 19 | @ | Tabor (NAIA) | 23 | | |
| LSC | SW Oklahoma St (D2) | 3 | @ | TAMU-Commerce (D2) | 21 | | |
| Wyoming | 13 | @ | Tennessee | 7 | | |
| OVC | Eastern Illinois | 24 | @ | Tennessee St | 45 | | |
| OVC | Jacksonville St | 41 | @ | Tennessee Tech | 17 | | |
| B12 | Baylor | 21 | @ | #3 Texas | 45 | | |
| B12 | #6 Oklahoma | 66 | @ | Texas A&M | 28 | | |
| Concordia AL (NAIA) (4-5) | | @ | Texas College (NAIA) (0-8) | | | |
| SWAC | Mississippi Valley St | 58 | @ | Texas Southern | 44 | | |
| B12 | #14 Oklahoma St | 20 | @ | #2 Texas Tech | 56 | | |
| TPAC | Waynesburg (D3) | 50 | @ | Thiel (D3) | 35 | | |
| Hillsdale (D2) | 37 | @ | Tiffin (D2) | 36 | | |
| UMWAC | Crown (NAIA) | 61 | @ | Trinity Bible (NAIA) | 26 | | |
| MSFA | St Francis IL (NAIA) | 28 | @ | Trinity Int'l (NAIA) | 3 | | |
| Western Kentucky | 7 | @ | Troy | 17 | | |
| SAC | Carson-Newman (D2) | 44 | @ | Tusculum (D2) | 45 | | |
| SIAC | Lane (D2) | 21 | @ | Tuskegee (D2) | 55 | | |
| Sacramento St | 29 | @ | UC-Davis | 19 | | |
| P10 | #23 Oregon St | 34 | @ | UCLA | 6 | | |
| NEF | Curry (D3) | 40 | @ | UMass-Dartmouth (D3) | 20 | | |
| D2Ind | North Greenville (D2) | 7 | @ | UNC-Pembroke (D2) | 21 | | |
| MSC | Campbellsville (NAIA) | 24 | @ | Union KY (NAIA) | 31 | | |
| LL | Merchant Marine (D3) | 14 | @ | Union NY (D3) | 42 | | |
| MW | New Mexico | 20 | @ | UNLV | 27 | | |
| Minnesota-Crookston (D2) | 36 | @ | Upper Iowa (D2) | 37 | | |
| E8 | Norwich (D3) | 25 | @ | Utica (D3) | 28 | | |
| WIAC | UW-Stevens Point (D3) | 21 | @ | UW-Eau Claire (D3) | 20 | | |
| WIAC | UW-River Falls (D3) | 19 | @ | UW-La Crosse (D3) | 49 | | |
| WIAC | UW-Platteville (D3) | 28 | @ | UW-Oshkosh (D3) | 0 | | |
| WIAC | UW-Stout (D3) | 10 | @ | UW-Whitewater (D3) | 17 | | |
| Pio | Jacksonville FL | 40 | @ | Valparaiso | 24 | | |
| SEC | #3 Florida | 42 | @ | Vanderbilt | 14 | | |
| CAAF | New Hampshire | 13 | @ | Villanova | 24 | | |
| BigS | Liberty | 38 | @ | VMI | 26 | | |
| NE | Duquesne | 14 | @ | Wagner | 0 | | |
| ACC | Virginia | 17 | @ | Wake Forest | 28 | | |
| Minnesota-Morris (NAIA) | 20 | @ | Waldorf (NAIA) | 0 | | |
| IIAC | Dubuque (D3) | 13 | @ | Wartburg (D3) | 20 | | |
| TPAC | Bethany WV (D3) | 7 | @ | Wash & Jeff (D3) | 54 | | |
| Nebraska-Omaha (D2) | 34 | @ | Washburn (D2) | 14 | | |
| P10 | Arizona St | 39 | @ | Washington | 19 | | |
| ODC | Emory & Henry (D3) | 17 | @ | Washington and Lee (D3) | 14 | | |
| P10 | Arizona | 59 | @ | Washington St | 28 | | |
| GLIAC | Grand Valley St (D2) | 24 | @ | Wayne St MI (D2) | 10 | | |
| NESCAA | Trinity CT (D3) | 38 | @ | Wesleyan (D3) | 14 | | |
| GSC | North Alabama (D2) | 41 | @ | West Alabama (D2) | 9 | | |
| GSC | Delta St (D2) | 68 | @ | West Georgia (D2) | 10 | | |
| LSC | Tarleton St (D2) | 0 | @ | West Texas A&M (D2) | 51 | | |
| BigE | #22 Cincinnati | 26 | @ | West Virginia | 23 | OT | |
| WVIAC | WV Wesleyan (D2) | 24 | @ | West Virginia St (D2) | 31 | | |
| Pikeville (NAIA) | 17 | @ | West Virginia Tech (D2) | 14 | | |
| NJAC | New Jersey (D3) | 30 | @ | Western Conn St (D3) | 20 | | |
| Illinois | 17 | vs | Western Michigan | 23 | | Detroit MI |
| RMAC | Fort Lewis (D2) | 24 | @ | Western New Mexico (D2) | 48 | | |
| NEF | Worcester St (D3) | 0 | @ | Westfield St (D3) | 41 | | |
| TPAC | Grove City (D3) | 21 | @ | Westminster PA (D3) | 24 | | |
| CCIW | Illinois Wesleyan (D3) | 10 | @ | Wheaton (D3) | 44 | | |
| NWC | Lewis & Clark (D3) | 7 | @ | Whitworth (D3) | 42 | | |
| MidAC | Delaware Valley (D3) | 28 | @ | Wilkes (D3) | 20 | | |
| NWC | Puget Sound (D3) | 27 | @ | Willamette (D3) | 49 | | |
| CAAF | Northeastern | 17 | @ | William & Mary | 38 | | |
| HAAC | Graceland (NAIA) | 7 | @ | William Jewell (NAIA) | 21 | | |
| OAC | Baldwin-Wallace (D3) | 21 | @ | Wilmington (D3) | 27 | | |
| SAC | Mars Hill (D2) | 45 | @ | Wingate (D2) | 42 | | |
| Benedictine IL (D3) | 14 | @ | Wisconsin Lutheran (D3) | 10 | | |
| SoCon | The Citadel | 28 | @ | Wofford | 33 | | |
| Susquehanna (D3) | 51 | @ | WPI (D3) | 21 | | |
| MVC | Indiana St | 21 | @ | Youngstown St | 35 | | |
| Tuesday, 11 Nov 2008 |
| MAC | #15 Ball St | 31 | @ | Miami OH | 16 | | |
| Wednesday, 12 Nov 2008 |
| MAC | Temple | 38 | @ | Kent St | 41 | | |
| MAC | Central Michigan | 33 | @ | Northern Illinois | 30 | OT | |