| 9/2/2010 | Cumberland TN @ Austin Peay | |
| 9/2/2010 | SE Missouri State @ Ball State | |
| 9/2/2010 | Murray State @ Kent State | |
| 9/2/2010 | Eastern Kentucky @ Missouri State | |
| 9/4/2010 | Tennessee Tech @ Arkansas | |
| 9/4/2010 | Eastern Illinois @ Iowa | |
| 9/4/2010 | Jacksonville State @ Mississippi | |
| 9/4/2010 | Tennessee-Martin @ Tennessee | |
| 9/4/2010 | Alabama A&M @ Tennessee State | |
| 9/11/2010 | Central Arkansas @ Eastern Illinois | |
| 9/11/2010 | Chattanooga @ Jacksonville State | |
| 9/11/2010 | Eastern Kentucky @ Louisville | |
| 9/11/2010 | Austin Peay @ Middle Tenn State | |
| 9/11/2010 | SE Missouri State @ Murray State | † |
| 9/11/2010 | Tennessee-Martin @ Southeastern Louisiana | |
| 9/11/2010 | Tennessee Tech @ TCU | |
| 9/11/2010 | Jackson State vs Tennessee State | |
| 9/16/2010 | Lane @ Tennessee Tech | |
| 9/18/2010 | Murray State @ Central Arkansas | |
| 9/18/2010 | Eastern Kentucky @ Chattanooga | |
| 9/18/2010 | Jacksonville State @ Georgia State | |
| 9/18/2010 | SE Missouri State @ Southern Illinois | |
| 9/18/2010 | Austin Peay @ Tennessee State | † |
| 9/18/2010 | Eastern Illinois @ Tennessee-Martin | † |
| 9/25/2010 | Jacksonville State @ Eastern Illinois | † |
| 9/25/2010 | Tennessee-Martin @ Murray State | † |
| 9/25/2010 | Tennessee Tech @ SE Missouri State | † |
| 9/25/2010 | Florida A&M vs Tennessee State | |
| 9/25/2010 | Austin Peay @ Wisconsin | |
| 9/30/2010 | Tennessee-Martin @ Tennessee Tech | † |
| 10/2/2010 | SE Missouri State @ Eastern Illinois | † |
| 10/2/2010 | Kentucky State @ Eastern Kentucky | |
| 10/2/2010 | Murray State @ Jacksonville State | † |
| 10/2/2010 | North Carolina A&T vs Tennessee State | |
| 10/9/2010 | Tennessee Tech @ Austin Peay | † |
| 10/9/2010 | Eastern Illinois @ Eastern Kentucky | † |
| 10/9/2010 | Missouri State @ Murray State | |
| 10/9/2010 | Tennessee State @ SE Missouri State | † |
| 10/9/2010 | Jacksonville State @ Tennessee-Martin | † |
| 10/16/2010 | SE Missouri State @ Austin Peay | † |
| 10/16/2010 | Tennessee State @ Jacksonville State | † |
| 10/16/2010 | Eastern Illinois @ Tennessee Tech | † |
| 10/16/2010 | Eastern Kentucky @ Tennessee-Martin | † |
| 10/21/2010 | Lambuth @ Tennessee-Martin | |
| 10/23/2010 | Murray State @ Eastern Illinois | † |
| 10/23/2010 | Austin Peay @ Jacksonville State | † |
| 10/23/2010 | Eastern Kentucky @ SE Missouri State | † |
| 10/23/2010 | Tennessee Tech @ Tennessee State | † |
| 10/30/2010 | Austin Peay @ Eastern Illinois | † |
| 10/30/2010 | Murray State @ Eastern Kentucky | † |
| 10/30/2010 | Tennessee-Martin @ SE Missouri State | † |
| 11/6/2010 | Tennessee-Martin @ Austin Peay | † |
| 11/6/2010 | Jacksonville State @ Eastern Kentucky | † |
| 11/6/2010 | Tennessee Tech @ Murray State | † |
| 11/6/2010 | Southwest Baptist @ SE Missouri State | |
| 11/6/2010 | Eastern Illinois @ Tennessee State | † |
| 11/13/2010 | Murray State @ Austin Peay | † |
| 11/13/2010 | Eastern Illinois @ Illinois State | |
| 11/13/2010 | SE Missouri State @ Jacksonville State | † |
| 11/13/2010 | Eastern Kentucky @ Tennessee Tech | † |
| 11/13/2010 | Tennessee State @ Tennessee-Martin | † |
| 11/20/2010 | Austin Peay @ Eastern Kentucky | † |
| 11/20/2010 | Tennessee State @ Murray State | † |
| 11/20/2010 | Jacksonville State @ Tennessee Tech | † |