| 9/2/2010 | Central Missouri Mules 54 @ Illinois State 55 | |
| 9/11/2010 | Illinois State 3 @ Northwestern Wildcats 37 | |
| 9/18/2010 | Illinois State 24 @ South Dakota State Jackrabbits 14 | † |
| 9/25/2010 | Missouri State Bears 41 @ Illinois State 44 1OT | † |
| 10/2/2010 | Southern Illinois Salukis 38 @ Illinois State 17 | † |
| 10/9/2010 | Illinois State 24 @ Indiana State Sycamores 59 | † |
| 10/16/2010 | North Dakota State Bison 24 @ Illinois State 34 | † |
| 10/23/2010 | Illinois State 14 @ Northern Iowa Panthers 42 | † |
| 10/30/2010 | Illinois State 38 @ Western Illinois Leathernecks 65 | † |
| 11/6/2010 | Youngstown State Penguins 39 @ Illinois State 41 | † |
| 11/13/2010 | Eastern Illinois Panthers 23 @ Illinois State 27 |