| 9/4/2010 | Appalachian State Mountaineers 42 @ Chattanooga 41 | † |
| 9/11/2010 | Chattanooga 17 @ Jacksonville State Gamecocks 21 | |
| 9/18/2010 | Eastern Kentucky Colonels 24 @ Chattanooga 42 | |
| 9/25/2010 | Chattanooga 27 @ Western Carolina Catamounts 21 | † |
| 10/9/2010 | Chattanooga 28 @ The Citadel Bulldogs 10 | † |
| 10/16/2010 | Georgia Southern Eagles 27 @ Chattanooga 35 | † |
| 10/23/2010 | Chattanooga 36 @ Furman Paladins 28 | † |
| 10/30/2010 | Elon Phoenix 49 @ Chattanooga 35 | † |
| 11/6/2010 | Chattanooga 24 @ Auburn Tigers 62 | |
| 11/13/2010 | Samford Bulldogs 14 @ Chattanooga 48 | † |
| 11/20/2010 | Chattanooga 14 @ Wofford Terriers 45 | † |