| 9/2/2010 | Cumberland TN 6 @ Austin Peay Governers 38 | |
| 9/11/2010 | Campbellsville Tigers 21 @ Cumberland TN 33 | † |
| 9/18/2010 | Cumberland TN 35 vs Kentucky Christian Knights 6 (Huntington WV) | † |
| 9/25/2010 | West Virginia Tech Golden Bears 7 @ Cumberland TN 30 | † |
| 10/2/2010 | Lindsey Wilson Blue Raiders 7 @ Cumberland TN 23 | † |
| 10/9/2010 | Shorter Hawks 14 @ Cumberland TN 22 | † |
| 10/16/2010 | Cumberland TN 17 @ Faulkner Eagles 20 | † |
| 10/23/2010 | Cumberland TN 23 @ Bethel TN Wildcats 17 | † |
| 10/30/2010 | Union KY Bulldogs 18 @ Cumberland TN 29 | † |
| 11/6/2010 | Belhaven Blazers 7 @ Cumberland TN 45 | † |
| 11/13/2010 | Cumberland TN 27 @ Cumberlands KY Patriots 52 | † |