| 9/2/2010 | Southeastern Louisiana 21 @ Tulane Green Wave 27 | |
| 9/11/2010 | Tennessee-Martin Skyhawks 10 @ Southeastern Louisiana 24 | |
| 9/18/2010 | Lamar Cardinals 29 @ Southeastern Louisiana 28 | † |
| 9/25/2010 | Southeastern Louisiana 20 @ UL Monroe Warhawks 21 | |
| 10/9/2010 | Texas State Bobcats 24 @ Southeastern Louisiana 49 | † |
| 10/16/2010 | Southeastern Louisiana 7 @ Sam Houston Bearkats 57 | † |
| 10/23/2010 | McNeese State Cowboys 13 @ Southeastern Louisiana 10 | † |
| 10/30/2010 | Southeastern Louisiana 23 @ Central Arkansas Bears 30 | † |
| 11/6/2010 | Northwestern State Demons 35 @ Southeastern Louisiana 16 | † |
| 11/13/2010 | Southeastern Louisiana 14 @ Stephen F. Austin Lumberjacks 51 | † |
| 11/18/2010 | Southeastern Louisiana 25 @ Nicholls State Colonels 27 | † |