| 9/4/2010 | Alabama A&M 14 @ Tennessee State Tigers 27 | |
| 9/11/2010 | Central State Marauders 0 @ Alabama A&M 45 | |
| 9/18/2010 | Alabama A&M 9 @ Texas Southern Tigers 32 | † |
| 9/25/2010 | Southern Jaquars 14 @ Alabama A&M 34 | † |
| 10/2/2010 | Grambling Tigers 25 @ Alabama A&M 22 | † |
| 10/9/2010 | Alabama A&M 14 @ Jackson State Tigers 30 | † |
| 10/16/2010 | Alabama A&M 14 @ Ark Pine Bluff Golden Lions 21 | † |
| 10/30/2010 | Alabama State Hornets 31 vs Alabama A&M 10 (Birmingham AL) | † |
| 11/6/2010 | Alcorn State Braves 41 @ Alabama A&M 24 | † |
| 11/13/2010 | Alabama A&M 21 @ Mississippi Valley State Delta Devils 7 | † |
| 11/20/2010 | Prairie View Panthers 35 @ Alabama A&M 14 | † |