| 9/2/2010 | Lambuth 19 @ Arkansas Tech Wonder Boys 34 |
| 9/11/2010 | Lambuth 23 @ Georgia State Panthers 14 |
| 9/18/2010 | Lambuth 14 @ West Alabama Tigers 13 |
| 9/25/2010 | North Alabama Lions 31 @ Lambuth 0 |
| 10/2/2010 | Lambuth 0 @ Harding Bison 27 |
| 10/16/2010 | Wisconsin-Oshkosh Titans 35 @ Lambuth 22 |
| 10/21/2010 | Lambuth 21 @ Tennessee-Martin Skyhawks 52 |
| 10/30/2010 | Central State Marauders 6 @ Lambuth 42 |
| 11/6/2010 | Edward Waters Tigers 27 @ Lambuth 44 |
| 11/13/2010 | Delta State Statesmen 41 @ Lambuth 17 |