| 9/4/2010 | Kentucky Wildcats 23 @ Louisville 16 | |
| 9/11/2010 | Eastern Kentucky Colonels 13 @ Louisville 23 | |
| 9/18/2010 | Louisville 28 @ Oregon State Beavers 35 | |
| 10/2/2010 | Louisville 34 @ Arkansas State Red Wolves 24 | |
| 10/9/2010 | Memphis Tigers 0 @ Louisville 56 | |
| 10/15/2010 | Cincinnati Bearcats 35 @ Louisville 27 | † |
| 10/23/2010 | Connecticut Huskies 0 @ Louisville 26 | † |
| 10/30/2010 | Louisville 3 @ Pittsburgh Panthers 21 | † |
| 11/6/2010 | Louisville 28 @ Syracuse Orangemen 20 | † |
| 11/13/2010 | South Florida Bulls 24 @ Louisville 21 1OT | † |
| 11/20/2010 | West Virginia Mountaineers 17 @ Louisville 10 | † |
| 11/26/2010 | Louisville 40 @ Rutgers Scarlet Knights 13 | † |
| 12/21/2010 | Southern Miss Golden Eagles 28 vs Louisville 31 (St Petersburg - Beef O'Brady's Bowl) |