| 8/28/2010 | Central Missouri Mules 60 @ Southwest Baptist 13 | |
| 9/4/2010 | Southwest Baptist 30 @ Truman State Bulldogs 33 | |
| 9/11/2010 | Bacone Warriors 12 @ Southwest Baptist 21 | |
| 9/18/2010 | William Jewell Cardinals 14 @ Southwest Baptist 59 | |
| 9/25/2010 | Southwest Baptist 69 @ Southern Nazarene Crimson Storm 27 | |
| 10/2/2010 | Southwest Baptist 50 @ Urbana Blue Knights 21 | |
| 10/9/2010 | Southwest Baptist 62 @ Lincoln MO Blue Tigers 38 | † |
| 10/23/2010 | Central State Marauders 0 @ Southwest Baptist 52 | |
| 10/30/2010 | St Joseph's Pumas 43 @ Southwest Baptist 51 | |
| 11/6/2010 | Southwest Baptist 14 @ SE Missouri State Redhawks 40 | |
| 11/13/2010 | Southwest Baptist 14 @ Arkansas Tech Wonder Boys 42 |