| 9/2/2010 | SE Missouri State Redhawks 10 @ Ball State 27 | |
| 9/11/2010 | Liberty Flames 27 @ Ball State 23 | |
| 9/18/2010 | Ball State 13 @ Purdue Boilermakers 24 | |
| 9/25/2010 | Ball State 0 @ Iowa Hawkeyes 45 | |
| 10/2/2010 | Ball State 31 @ Central Michigan Chippewas 17 | † |
| 10/9/2010 | Western Michigan Broncos 45 @ Ball State 16 | † |
| 10/16/2010 | Eastern Michigan Eagles 41 @ Ball State 38 1OT | † |
| 10/23/2010 | Ball State 24 @ Toledo Rockets 31 | † |
| 10/30/2010 | Ball State 14 @ Kent State Golden Flashes 33 | † |
| 11/6/2010 | Akron Zips 30 @ Ball State 37 2OT | † |
| 11/12/2010 | Ball State 20 @ Buffalo Bulls 3 | † |
| 11/20/2010 | Northern Illinois Huskies 59 @ Ball State 21 | † |