| 8/28/2010 | Clark Atlanta Panthers 20 @ Lane 6 | † |
| 9/4/2010 | Lane 14 vs Kentucky State Thorobreds 27 (Lexington KY) | † |
| 9/11/2010 | Lane 6 @ Morehouse Maroon Tigers 49 | † |
| 9/16/2010 | Lane 0 @ Tennessee Tech Golden Eagles 43 | |
| 10/2/2010 | Lane 13 @ Albany State GA Golden Rams 43 | † |
| 10/9/2010 | Benedict Tigers 30 @ Lane 23 | † |
| 10/16/2010 | Miles Golden Bears 20 @ Lane 6 | † |
| 10/23/2010 | Stillman Tigers 26 @ Lane 25 | † |
| 10/30/2010 | Fort Valley State Wildcats 31 @ Lane 18 | † |
| 11/6/2010 | Lane 6 @ Tuskegee Golden Tigers 28 | † |