| 9/4/2010 | Winston-Salem State Rams 21 @ North Carolina A&T 14 | |
| 9/11/2010 | North Carolina A&T 14 @ Norfolk State Spartans 23 | † |
| 9/18/2010 | North Carolina A&T 21 @ Hampton Pirates 35 | † |
| 9/25/2010 | North Carolina A&T 16 @ North Carolina Central Eagles 27 | |
| 10/2/2010 | North Carolina A&T 7 vs Tennessee State Tigers 37 (Indianapolis IN) | |
| 10/9/2010 | Morgan State Golden Bears 27 @ North Carolina A&T 14 | † |
| 10/16/2010 | North Carolina A&T 26 @ Delaware State Hornets 31 | † |
| 10/23/2010 | Howard Bison 32 @ North Carolina A&T 52 | † |
| 10/28/2010 | North Carolina A&T 17 @ Bethune-Cookman Wildcats 67 | † |
| 11/6/2010 | Florida A&M Rattlers 22 @ North Carolina A&T 19 1OT | † |
| 11/20/2010 | South Carolina State Bulldogs 48 @ North Carolina A&T 3 | † |