| 9/4/2010 | Delta State Statesmen 17 @ Jackson State 32 | |
| 9/11/2010 | Jackson State 33 vs Tennessee State Tigers 26 (Memphis TN) | |
| 9/18/2010 | Jackson State 21 @ Grambling Tigers 28 | † |
| 9/25/2010 | Mississippi Valley State Delta Devils 7 @ Jackson State 43 | † |
| 10/9/2010 | Alabama A&M Bulldogs 14 @ Jackson State 30 | † |
| 10/16/2010 | Southern Jaquars 45 @ Jackson State 49 | † |
| 10/23/2010 | Jackson State 18 @ Texas Southern Tigers 21 | † |
| 10/30/2010 | Prairie View Panthers 13 @ Jackson State 30 | † |
| 11/6/2010 | Jackson State 30 @ Alabama State Hornets 32 | † |
| 11/13/2010 | Jackson State 52 @ Ark Pine Bluff Golden Lions 30 | † |
| 11/20/2010 | Alcorn State Braves 14 @ Jackson State 27 | † |