| 9/2/2010 | Elizabeth City State Vikings 20 @ Central Arkansas 47 | |
| 9/11/2010 | Central Arkansas 37 @ Eastern Illinois Panthers 7 | |
| 9/18/2010 | Murray State Racers 20 @ Central Arkansas 21 | |
| 9/25/2010 | Central Arkansas 14 @ Tulsa Golden Hurricane 41 | |
| 10/9/2010 | Northwestern State Demons 24 @ Central Arkansas 19 | † |
| 10/16/2010 | Central Arkansas 7 @ Stephen F. Austin Lumberjacks 30 | † |
| 10/23/2010 | Central Arkansas 31 @ Nicholls State Colonels 7 | † |
| 10/30/2010 | Southeastern Louisiana Lions 23 @ Central Arkansas 30 | † |
| 11/6/2010 | Central Arkansas 49 @ Texas State Bobcats 17 | † |
| 11/13/2010 | Sam Houston Bearkats 20 @ Central Arkansas 13 | † |
| 11/20/2010 | McNeese State Cowboys 24 @ Central Arkansas 28 | † |