| 9/2/2010 | Central Missouri @ Illinois State | |
| 9/2/2010 | Eastern Kentucky @ Missouri State | |
| 9/2/2010 | Quincy @ Southern Illinois | |
| 9/2/2010 | Valparaiso @ Western Illinois | |
| 9/4/2010 | St Joseph's @ Indiana State | |
| 9/4/2010 | North Dakota State @ Kansas | |
| 9/4/2010 | Youngstown State @ Penn State | |
| 9/11/2010 | Indiana State @ Cincinnati | |
| 9/11/2010 | South Dakota State @ Delaware | |
| 9/11/2010 | Southern Illinois @ Illinois | |
| 9/11/2010 | Missouri State @ Kansas State | |
| 9/11/2010 | North Dakota State @ Northern Iowa | † |
| 9/11/2010 | Illinois State @ Northwestern | |
| 9/11/2010 | Western Illinois @ Purdue | |
| 9/11/2010 | Butler @ Youngstown State | |
| 9/18/2010 | Morgan State @ North Dakota State | |
| 9/18/2010 | Stephen F. Austin @ Northern Iowa | |
| 9/18/2010 | Illinois State @ South Dakota State | † |
| 9/18/2010 | SE Missouri State @ Southern Illinois | |
| 9/18/2010 | Sam Houston @ Western Illinois | |
| 9/18/2010 | Central Conn @ Youngstown State | |
| 9/25/2010 | Missouri State @ Illinois State | † |
| 9/25/2010 | Northern Iowa @ Iowa State | |
| 9/25/2010 | South Dakota State @ Nebraska | |
| 9/25/2010 | South Dakota @ North Dakota State | |
| 9/25/2010 | Indiana State @ Western Illinois | † |
| 9/25/2010 | Southern Illinois @ Youngstown State | † |
| 10/2/2010 | Southern Illinois @ Illinois State | † |
| 10/2/2010 | Quincy @ Indiana State | |
| 10/2/2010 | Youngstown State @ Missouri State | † |
| 10/2/2010 | Western Illinois @ North Dakota State | † |
| 10/2/2010 | South Dakota State @ Northern Iowa | † |
| 10/9/2010 | Illinois State @ Indiana State | † |
| 10/9/2010 | Missouri State @ Murray State | |
| 10/9/2010 | Western Illinois @ South Dakota State | † |
| 10/9/2010 | Northern Iowa @ Southern Illinois | † |
| 10/9/2010 | North Dakota State @ Youngstown State | † |
| 10/16/2010 | North Dakota State @ Illinois State | † |
| 10/16/2010 | Missouri State @ Indiana State | † |
| 10/16/2010 | Northern Iowa @ South Dakota | |
| 10/16/2010 | South Dakota State @ Southern Illinois | † |
| 10/16/2010 | Youngstown State @ Western Illinois | † |
| 10/23/2010 | Western Illinois @ Missouri State | † |
| 10/23/2010 | Indiana State @ North Dakota State | † |
| 10/23/2010 | Illinois State @ Northern Iowa | † |
| 10/23/2010 | Youngstown State @ South Dakota State | † |
| 10/30/2010 | South Dakota State @ Indiana State | † |
| 10/30/2010 | Southern Illinois @ Missouri State | † |
| 10/30/2010 | Illinois State @ Western Illinois | † |
| 10/30/2010 | Northern Iowa @ Youngstown State | † |
| 11/6/2010 | Youngstown State @ Illinois State | † |
| 11/6/2010 | Northern Iowa @ Indiana State | † |
| 11/6/2010 | Southern Illinois @ North Dakota State | † |
| 11/6/2010 | Missouri State @ South Dakota State | † |
| 11/13/2010 | Eastern Illinois @ Illinois State | |
| 11/13/2010 | South Dakota State @ North Dakota State | † |
| 11/13/2010 | Missouri State @ Northern Iowa | † |
| 11/13/2010 | Western Illinois @ Southern Illinois | † |
| 11/13/2010 | Indiana State @ Youngstown State | † |
| 11/20/2010 | North Dakota State @ Missouri State | † |
| 11/20/2010 | North Dakota @ South Dakota State | |
| 11/20/2010 | Indiana State @ Southern Illinois | † |
| 11/20/2010 | Northern Iowa @ Western Illinois | † |